ArticlePloS one2008
Polarized growth in the absence of F-actin in Saccharomyces cerevisiae exiting quiescence.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Roles for the canonical polarity machinery in the de novo establishment of polarity in budding yeast spores.Molecular biology of the cell · 2025Article
- Roles for the canonical polarity machinery in thebioRxiv : the preprint server for biology · 2025Article
- Wbm0076, a candidate effector protein of the Wolbachia endosymbiont of Brugia malayi, disrupts eukaryotic actin dynamics.PLoS pathogens · 2023Article
- A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae.Genetics · 2022Article
- Identification of putative effectors of the Type IV secretion system from the Wolbachia endosymbiont of Brugia malayi.PloS one · 2018Article
- Yeast quiescence exit swiftness is influenced by cell volume and chronological age.Microbial cell (Graz, Austria) · 2017Article
- Evidence for a Role for the Plasma Membrane in the Nanomechanical Properties of the Cell Wall as Revealed by an Atomic Force Microscopy Study of the Response of Saccharomyces cerevisiae to Ethanol Stress.Applied and environmental microbiology · 2016Article
- Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.Science signaling · 2016Article
- Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity.Molecular and cellular biology · 2016Article
- Uncovering by atomic force microscopy of an original circular structure at the yeast cell surface in response to heat shock.BMC biology · 2014Article
- An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence.The Journal of cell biology · 2013Article
- Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.Developmental cell · 2013Article
- Cell polarization and cytokinesis in budding yeast.Genetics · 2012Review
- Morphogenesis and the cell cycle.Genetics · 2012Review
- Proliferation/quiescence: the controversial "aller-retour".Cell division · 2011Article
- Metabolic status rather than cell cycle signals control quiescence entry and exit.The Journal of cell biology · 2011Article
- Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.Molecular biology of the cell · 2011Article
- Polarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretion.Molecular biology of the cell · 2010Article
- Initial polarized bud growth by endocytic recycling in the absence of actin cable-dependent vesicle transport in yeast.Molecular biology of the cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolarity establishment and maintenance are crucial for morphogenesis and development. In budding yeast, these two intricate processes involve the superposition of regulatory loops between polarity landmarks, RHO GTPases, actin-mediated vesicles transport and endocytosis. Deciphering the chronology and the significance of each molecular step of polarized growth is therefore very challenging. PRINCIPAL
findingsWe have taken advantage of the fact that yeast quiescent cells display actin bodies, a non polarized actin structure, to evaluate the role of F-actin in bud emergence. Here we show that upon exit from quiescence, actin cables are not required for the first steps of polarized growth. We further show that polarized growth can occur in the absence of actin patch-mediated endocytosis. We finally establish, using latrunculin-A, that the first steps of polarized growth do not require any F-actin containing structures. Yet, these structures are required for the formation of a bona fide daughter cell and cell cycle completion. We propose that upon exit from quiescence in the absence of F-actin, secretory vesicles randomly reach the plasma membrane but preferentially dock and fuse where polarity cues are localized, this being sufficient to trigger polarized growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.