ArticlePediatric research2008
Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs.
Article in Pediatric research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Molecular and cellular pediatrics · 2023Review
- The Respiratory Management of the Extreme Preterm in the Delivery Room.Children (Basel, Switzerland) · 2023Review
- Expired Tidal Volume and Respiratory Rate During Postnatal Stabilization of Newborn Infants Born at Term via Cesarean Delivery.The journal of pediatrics: X · 2021Article
- [Newborn resuscitation and support of transition of infants at birth].Notfall & rettungsmedizin · 2021Review
- Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles.Scientific reports · 2017Article
- Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.Pediatric research · 2017Article
- Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep.Pediatric research · 2017Article
- Selection of Reference Genes for Gene Expression Studies related to lung injury in a preterm lamb model.Scientific reports · 2016Article
- Differential short-term regional effects of early high dose erythropoietin on white matter in preterm lambs after mechanical ventilation.The Journal of physiology · 2016Article
- Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator's Training.PloS one · 2016Article
- Pressure-limited sustained inflation vs. gradual tidal inflations for resuscitation in preterm lambs.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Unraveling the Links Between the Initiation of Ventilation and Brain Injury in Preterm Infants.Frontiers in pediatrics · 2015Review
- Prophylactic erythropoietin exacerbates ventilation-induced lung inflammation and injury in preterm lambs.The Journal of physiology · 2014Article
- Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs.BMC pediatrics · 2014Article
- Protective ventilation of preterm lambs exposed to acute chorioamnionitis does not reduce ventilation-induced lung or brain injury.PloS one · 2014Article
- Marked variation in delivery room management in very preterm infants.Resuscitation · 2013Article
- Noninvasive Monitoring during Interhospital Transport of Newborn Infants.Critical care research and practice · 2013Article
- Short- and intermediate-term outcomes of preterm infants receiving positive pressure ventilation in the delivery room.Critical care research and practice · 2013Article
- Physiology of transition from intrauterine to extrauterine life.Clinics in perinatology · 2012Review
- Marked variation in newborn resuscitation practice: a national survey in the UK.Resuscitation · 2012Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Positive end-expiratory pressure (PEEP) protects the lung from injury during sustained ventilation, but its role in protecting the lung from injury during the initiation of ventilation in the delivery room is not established. We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-min of ventilation are protective against lung injury. Operatively delivered preterm lambs (133 +/- 1 d gestation) were randomly assigned to unventilated controls or to one of four 15 min ventilation interventions: 1) VT15 mL/kg, PEEP 0 cm H2O; 2) VT15 mL/kg, PEEP 5 cm H2O; 3) VT8 mL/kg, PEEP 0 cm H2O; and 4) VT8 mL/kg, PEEP 5 cm H2O. Each group was subsequently ventilated with VT 10 mL/kg, PEEP 5 cm H2O for 1 h 45 min. Lung function was assessed and measurements of lung injury were evaluated postmortem. After the 15 min ventilation maneuver, the VT15 groups were hypocarbic, had higher oxygenation, and required lower pressures than the VT8 groups; no consistent effect of PEEP was found. Markers of lung injury were significantly elevated in all ventilation groups compared with unventilated controls; no effect of PEEP was found. Ventilation resulted in localization of IL-6 to the small airways. Initial ventilation of preterm lambs with PEEP and/or VT of 8 mL/kg did not prevent an inflammatory injury to the lung.
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Registered trials
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