ArticleJPEN. Journal of parenteral and enteral nutrition
Cecal infusion of butyrate does not alter cecal concentration of butyrate in piglets fed inulin.
Article in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Estimating the contribution of the porcine fecal core microbiota to metabolite production via mathematical modeling andmSystems · 2024Article
- Major cereal carbohydrates in relation to intestinal health of monogastric animals: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Review
- Butyrate-producing bacteria, including mucin degraders, from the swine intestinal tract.Applied and environmental microbiology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCecal or distal colonic concentration of butyrate has been used as an index of butyrate production from various fermentable carbohydrates. However, we previously found that cecal concentration of butyrate does not correlate with the rate of synthesis of butyrate in the cecal lumen. As part of a larger study of the cellular effects of cecal infusions of butyrate, we sought to rule out the null hypothesis that cecal infusion of butyrate also would not alter butyrate concentration in the cecum.
methodsPiglets (n = 10) were fed sow milk replacement formula plus inulin (3 g x L(-1)). After 6 days of oral feeding, the piglets were randomly assigned into 2 equal groups: (I) Cecal infusion of phosphate-buffered NaCl and (II) cecal infusion of butyrate (2.13 micromol x kg(-1) x min(-1)). The concentration of butyrate was measured by gas chromatography in the cecum and distal colon.
resultsThere was no effect of cecal butyrate infusion on butyrate concentration (mM; I vs II) in the cecum (5.7 +/- 0.4 vs 5.3 +/- 1.1) or distal colon (3.3 +/- 0.6 vs 4.1 +/- 0.8) or on the ratio of cecal butyrate concentration to the sum of the concentrations of butyrate, acetate, propionate, and valerate (0.101 +/- 0.004 vs 0.083 +/- 0.011). There was no effect of cecal butyrate infusion on the concentration of any of these short chain fatty acids.
conclusionsAt an entry rate into the cecum within the physiological range, butyrate had no effect on cecal or distal colonic luminal concentration of butyrate.
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