Trial reportJPEN. Journal of parenteral and enteral nutrition
Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients.
Trial report in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 10 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The role of nutritional supplementation in preventing postoperative complications: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Prevention of infection in aortic or aortoiliac peripheral arterial reconstruction.The Cochrane database of systematic reviews · 2025Pooled it
- The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.Nutrients · 2021Pooled it
- What is the evidence for the use of parenteral nutrition (PN) in critically ill surgical patients: a systematic review and meta-analysis.Techniques in coloproctology · 2018Pooled it
- Glutamine Supplementation in Intensive Care Patients: A Meta-Analysis of Randomized Clinical Trials.Medicine · 2015Pooled it
- Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis.Nutrients · 2015Pooled it
- Glutamine supplementation for young infants with severe gastrointestinal disease.The Cochrane database of systematic reviews · 2014Pooled it
- Glutamine supplementation for critically ill adults.The Cochrane database of systematic reviews · 2014Pooled it
- Parenteral glutamine supplementation in critical illness: a systematic review.Critical care (London, England) · 2014Pooled it
- The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2014Pooled it
- Efficacy and Safety of Glutamine-supplemented Parenteral Nutrition in Surgical ICU Patients: An American Multicenter Randomized Controlled Trial.Annals of surgery · 2016Trial
- Prolonged continuous intravenous infusion of the dipeptide L-alanine- L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury.Critical care (London, England) · 2014Trial
- Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention.Cancers · 2024Review
- Occurrence of Multidrug-Resistant Strains ofTropical medicine and infectious disease · 2023Article
- Dynamic Gene Clusters Mediating Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.Journal of leukocyte biology · 2019Article
- Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction.PloS one · 2019Article
- Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation.Nutrients · 2018Review
- Exogenous Glutamine in Respiratory Diseases: Myth or Reality?Nutrients · 2016Review
- Uncertainty about the safety of supplemental glutamine: an editorial on "A randomized trial of glutamine and antioxidants in critically ill patients".Hepatobiliary surgery and nutrition · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNosocomial infections are an important cause of morbidity and mortality in the surgical intensive care unit (SICU). Clinical benefits of glutamine-supplemented parenteral nutrition may occur in hospitalized surgical patients, but efficacy data in different surgical subgroups are lacking. The objective was to determine whether glutamine-supplemented parenteral nutrition differentially affects nosocomial infection rates in selected subgroups of SICU patients.
methodsThis was a double-blind, randomized, controlled study of alanyl-glutamine dipeptide-supplemented parenteral nutrition in SICU patients requiring parenteral nutrition and SICU care after surgery for pancreatic necrosis, cardiac, vascular, or colonic surgery. Subjects (n = 59) received isocaloric/isonitrogenous parenteral nutrition, providing 1.5 g/kg/d standard glutamine-free amino acids (STD-PN) or 1.0 g/kg/d standard amino acids + 0.5 g/kg/d glutamine dipeptide (GLN-PN). Enteral feedings were advanced as tolerated. Nosocomial infections were determined until hospital discharge.
resultsBaseline clinical/metabolic data were similar between groups. Plasma glutamine concentrations were low in all groups and were increased by GLN-PN. GLN-PN did not alter infection rates after pancreatic necrosis surgery (17 STD-PN and 15 GLN-PN patients). In nonpancreatic surgery patients (12 STD-PN and 15 GLN-PN), GLN-PN was associated with significantly decreased total nosocomial infections (STD-PN 36 vs GLN-PN 13, P < .030), bloodstream infections (7 vs 0, P < .01), pneumonias (16 vs 6, P < .05), and infections attributed to Staphylococcus aureus (P < .01), fungi, and enteric Gram-negative bacteria (each P < .05).
conclusionsGlutamine dipeptide-supplemented parenteral nutrition did not alter infection rates following pancreatic necrosis surgery but significantly decreased infections in SICU patients after cardiac, vascular, and colonic surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.