ArticlePsychosomatic medicine2008
Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys.
Article in Psychosomatic medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial.Brain, behavior, and immunity · 2023Trial
- Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial.Psychosomatic medicine · 2014Trial
- Low circulating adropin concentrations identify vulnerability in learning-dependent cognitive performance in aged rhesus macaques.npj aging · 2026Article
- Nonhuman primate abnormal behavior: Etiology, assessment, and treatment.American journal of primatology · 2022Review
- Combined rs-fMRI study on brain functional imaging and mechanism of RAGE-DAMPs of depression: Evidence from MDD patients to chronic stress-induced depression models in cynomolgus monkeys and mice.Clinical and translational medicine · 2021Article
- A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis).International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Article
- Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates.GeroScience · 2017Article
- Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates.Menopause (New York, N.Y.) · 2017Article
- The impact of treatment with selective serotonin reuptake inhibitors on primate cardiovascular disease, behavior, and neuroanatomy.Neuroscience and biobehavioral reviews · 2017Review
- The epigenetic impacts of social stress: how does social adversity become biologically embedded?Epigenomics · 2016Review
- Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys.Psychoneuroendocrinology · 2016Article
- Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates.Neuropharmacology · 2015Article
- High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates.Psychosomatic medicine · 2015Article
- Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys.Neuroscience letters · 2014Article
- Adipose tissue density, a novel biomarker predicting mortality risk in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression.Biological psychiatry · 2013Article
- Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates.Experimental neurology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine depressive behavior and early coronary artery atherogenesis in 36 socially housed female cynomolgus monkeys, an established model of atherogenesis and depression. Coronary heart disease (CHD) is caused by coronary artery atherosclerosis (CAA) and its sequelae which develop over a period of decades. Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac events. Little is known about the relationship between depression and CAA.
methodsThe monkeys were free of atherosclerosis before being fed a diet containing moderate amounts of fat and cholesterol for 52 months. Depressed behavior and activity levels recorded in weekly 15-minute focal samples, telemetered 24-hour heart rate, plasma total (TPC) and high-density lipoprotein cholesterol (HDLC), luteal phase serum progesterone concentrations, basal cortisol, cortisol response to corticotrophin-releasing hormone (CRH), and CAA extent were assessed.
resultsTime spent in depressed behavior over 4 years was significantly associated with early CAA (r = .73, p < .001), as were activity level, 24-hour heart rate, TPC, HDLC, cortisol response to CRH, and mean peak progesterone (all p < or = 0.05). Depressed females had four times the CAA compared with nondepressed females.
conclusionsDepression in primates is associated with perturbations in multiple CHD risk factors and accelerated early atherogenesis. These data are consistent with the hypotheses that depression and CAA both stem from a common mechanism and that depression may cause CAA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.