ArticleBlood2008
A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 89 citations in OpenAlex.
- Platelet-derived mitochondrial transfer in cancer metastasis: mechanisms, functional consequences, and translational opportunities.Clinical & experimental metastasis · 2026Review
- A computational framework for the investigation of phosphoinositide regulation.PLoS computational biology · 2025Article
- Antiplatelet Monotherapies for Long-Term Secondary Prevention Following Percutaneous Coronary Intervention.Journal of clinical medicine · 2025Review
- Modeling platelet P2YBiophysical journal · 2025Article
- Platelet activation near point-like source of agonist: Experimental insights and computational model.PloS one · 2024Article
- A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability.Pharmaceutics · 2023Review
- Cytosolic and mitochondrial CaPlatelets · 2021Article
- Multi-omics approaches for revealing the complexity of cardiovascular disease.Briefings in bioinformatics · 2021Review
- A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data.Scientific reports · 2020Article
- Optical uncaging of ADP reveals the early calcium dynamics in single, freely moving platelets.Biomedical optics express · 2020Article
- Multiscale systems biology of trauma-induced coagulopathy.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- A Mathematical Model of the Phosphoinositide Pathway.Scientific reports · 2018Article
- Method for the simulation of blood platelet shape and its evolution during activation.PLoS computational biology · 2018Article
- Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets.International journal of molecular sciences · 2018Article
- Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review.Frontiers in physiology · 2018Review
- VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways.NPJ systems biology and applications · 2018Article
- Article
- LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets.JCI insight · 2017Article
- Multi-Constituent Simulation of Thrombus Deposition.Scientific reports · 2017Article
- Systems Analysis of Thrombus Formation.Circulation research · 2016Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
To quantify how various molecular mechanisms are integrated to maintain platelet homeostasis and allow responsiveness to adenosine diphosphate (ADP), we developed a computational model of the human platelet. Existing kinetic information for 77 reactions, 132 fixed kinetic rate constants, and 70 species was combined with electrochemical calculations, measurements of platelet ultrastructure, novel experimental results, and published single-cell data. The model accurately predicted: (1) steady-state resting concentrations for intracellular calcium, inositol 1,4,5-trisphosphate, diacylglycerol, phosphatidic acid, phosphatidylinositol, phosphatidylinositol phosphate, and phosphatidylinositol 4,5-bisphosphate; (2) transient increases in intracellular calcium, inositol 1,4,5-trisphosphate, and G(q)-GTP in response to ADP; and (3) the volume of the platelet dense tubular system. A more stringent test of the model involved stochastic simulation of individual platelets, which display an asynchronous calcium spiking behavior in response to ADP. Simulations accurately reproduced the broad frequency distribution of measured spiking events and demonstrated that asynchronous spiking was a consequence of stochastic fluctuations resulting from the small volume of the platelet. The model also provided insights into possible mechanisms of negative-feedback signaling, the relative potency of platelet agonists, and cell-to-cell variation across platelet populations. This integrative approach to platelet biology offers a novel and complementary strategy to traditional reductionist methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.