ArticleAmerican journal of physiology. Cell physiology2009
Febrile temperature leads to significant stiffening of Plasmodium falciparum parasitized erythrocytes.
Article in American journal of physiology. Cell physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Extracellular vesicles participate in proteostasis and heat shock adaptation inEmerging microbes & infections · 2026Article
- Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance.Medical sciences (Basel, Switzerland) · 2026Review
- Physiological febrile heat stress increases cytoadhesion through increased protein trafficking ofeLife · 2026Article
- Temporal and spatial trends of the prevalence of infections caused by Plasmodium parasites among rural community members in three regions with varying transmission intensities in Mainland Tanzania.Malaria journal · 2025Article
- Febrile temperature enhancesbioRxiv : the preprint server for biology · 2025Article
- Article
- The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum.Advances in experimental medicine and biology · 2021Article
- Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions.Scientific reports · 2020Article
- Temperature-Induced Catch-Slip to Slip Bond Transit in Plasmodium falciparum-Infected Erythrocytes.Biophysical journal · 2020Article
- Conformational Distortions of the Red Blood Cell Spectrin Matrix Nanostructure in Response to Temperature ChangesScanning · 2019Article
- Hypercompliant apical membranes of bladder umbrella cells.Biophysical journal · 2014Article
- Turning up the heat: heat stress induces markers of programmed cell death in Plasmodium falciparum in vitro.Cell death & disease · 2013Article
- Viscoelasticity as a biomarker for high-throughput flow cytometry.Biophysical journal · 2013Article
- Cytoadherence of erythrocytes invaded by Plasmodium falciparum: quantitative contact-probing of a human malaria receptor.Acta biomaterialia · 2013Article
- Cytoadherence and severe malaria.The Malaysian journal of medical sciences : MJMS · 2012Article
- Multiscale modeling of red blood cell mechanics and blood flow in malaria.PLoS computational biology · 2011Article
- Biophotonic techniques for the study of malaria-infected red blood cells.Medical & biological engineering & computing · 2010Review
- Measurement of red blood cell mechanics during morphological changes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cell-Matrix De-Adhesion Dynamics Reflect Contractile Mechanics.Cellular and molecular bioengineering · 2009Article
- Phenotypic Screens Identify Parasite Genetic Factors Associated with Malarial Fever Response inmSphereArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Parasitic infection with Plasmodium falciparum is responsible for the most severe form of human malaria in which patients suffer from periodic fever. It is well established that during intra-erythrocytic maturation of the parasite in the red blood cell (RBC), the RBC becomes significantly more cytoadhesive and less deformable; these and other biochemical factors together with human host factors such as compromised immune status are important contributors to the disease pathology. There is currently substantial interest in understanding the loss of RBC deformability due to P. falciparum infection, but few results are available concerning effects of febrile conditions or parasitization on RBC membrane rheology. Here, for the first time, we report rheology of the single, isolated RBC with and without P. falciparum merozoite invasion, spanning a range from room temperature to febrile conditions (41 degrees C), over all the stages of parasite maturation. As expected, stiffness increased with parasite maturation. Surprisingly, however, stiffness increased acutely with temperature on a scale of minutes, particularly in late trophozoite and schizont stages. This acute stiffening in late falciparum stages may contribute to fever-dependent pathological consequences in the microcirculation.
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Registered trials
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