ArticleNucleic acids research2008
Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- IBtkα Activates the β-Catenin-Dependent Transcription ofInternational journal of molecular sciences · 2022Article
- Bacteriophage-ResistantViruses · 2021Article
- Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α.Journal of molecular medicine (Berlin, Germany) · 2019Article
- IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis.Cell death & disease · 2019Article
- CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis.Nature cell biology · 2018Article
- Aminode: Identification of Evolutionary Constraints in the Human Proteome.Scientific reports · 2018Article
- The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis.Cell death & disease · 2018Article
- The neonicotinoid insecticide Clothianidin adversely affects immune signaling in a human cell line.Scientific reports · 2017Article
- Article
- Peptide-guided targeting of GPR55 for anti-cancer therapy.Oncotarget · 2017Article
- IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.International journal of molecular sciences · 2016Article
- A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.Oncogene · 2016Article
- The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Oncotarget · 2015Article
- Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice.Scientific reports · 2015Article
- CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.The Journal of biological chemistry · 2015Article
- Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.Disease models & mechanisms · 2014Article
- Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα.Molecular biology of the cell · 2014Article
- fourSig: a method for determining chromosomal interactions in 4C-Seq data.Nucleic acids research · 2014Article
- Cancer-associated CD43 glycoforms as target of immunotherapy.Molecular cancer therapeutics · 2014Article
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Bruton's tyrosine kinase (Btk) is required for B-cell development. Btk deficiency causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Btk lacks a negative regulatory domain and may rely on cytoplasmic proteins to regulate its activity. Consistently, we identified an inhibitor of Btk, IBtk, which binds to the PH domain of Btk and down-regulates the Btk kinase activity. IBtk is an evolutionary conserved protein encoded by a single genomic sequence at 6q14.1 cytogenetic location, a region of recurrent chromosomal aberrations in lymphoproliferative disorders; however, the physical and functional organization of IBTK is unknown. Here, we report that the human IBTK locus includes three distinct mRNAs arising from complete intron splicing, an additional polyadenylation signal and a second transcription start site that utilizes a specific ATG for protein translation. By northern blot, 5'RACE and 3'RACE we identified three IBTKalpha, IBTKbeta and IBTKgamma mRNAs, whose transcription is driven by two distinct promoter regions; the corresponding IBtk proteins were detected in human cells and mouse tissues by specific antibodies. These results provide the first characterization of the human IBTK locus and may assist in understanding the in vivo function of IBtk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.