Trial reportPediatrics2008
Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study.
Trial report in Pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 7 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Pooled it
- A systematic review of adverse drug events associated with administration of common asthma medications in children.PloS one · 2017Pooled it
- Patient- and parent-initiated oral steroids for asthma exacerbations.The Cochrane database of systematic reviews · 2016Pooled it
- Pooled it
- Nedocromil sodium for chronic asthma in children.The Cochrane database of systematic reviews · 2006Pooled it
- 2020 Brazilian Thoracic Association recommendations for the management of asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaGuideline
- A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment.The pharmacogenomics journal · 2017Trial
- Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.The Journal of allergy and clinical immunology · 2015Trial
- Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.The Journal of allergy and clinical immunology · 2012Trial
- Risk factors for montelukast treatment failure in step-down therapy for controlled asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2011Trial
- Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial.BMJ (Clinical research ed.) · 2010Trial
- Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents.The Journal of pediatrics · 2009Trial
- Estimation of short-course systemic corticosteroid risks on adverse outcomes in childhood asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study.Frontiers in pharmacology · 2026Article
- Short Course of Systemic Steroids for Acute Respiratory Diseases During Infancy and Final Adult Height, Weight, and BMI: Preliminary Results from a Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Dangers of under-treatment and over-treatment with inhaled corticosteroids in children with asthma.Pediatric pulmonology · 2025Article
- Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches.International journal of molecular sciences · 2024Review
- Evaluation of vitamin D deficiency and low bone mass in children with asthma in fars province: A case-control study.Health science reports · 2024Article
- Inhaled Corticosteroid Exposure in Hospitalized Infants with Bronchopulmonary Dysplasia.American journal of perinatology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSystemic corticosteroids are known to induce osteoporosis and increase the risk for fractures in adults and children. Inhaled corticosteroids have been shown to increase the risk for osteoporosis and fractures in adults at risk; however, long-term prospective studies of children to assess risks of multiple short courses of oral corticosteroids and chronic inhaled corticosteroids have not been performed. Thus, we assessed the effects of multiple short courses of oral corticosteroids and long-term inhaled corticosteroids on bone mineral accretion over a period of years.
methodsThis was a cohort follow-up study for a median of 7 years of children who had mild-to-moderate asthma and initially were randomly assigned into the Childhood Asthma Management Program trial. Serial dual-energy radiograph absorptiometry scans of the lumbar spine for bone mineral density were performed for all patients. Annual bone mineral accretion was calculated for 531 boys and 346 girls who had asthma and were aged 5 to 12 years at baseline (84% of the initial cohort).
resultsOral corticosteroid bursts produced a dosage-dependent reduction in bone mineral accretion (0.052, 0.049, and 0.046 g/cm(2) per year) and an increase in risk for osteopenia (10%, 14%, and 21%) for 0, 1 to 4, and >or=5 courses, respectively, in boys but not girls. Cumulative inhaled corticosteroid use was associated with a small decrease in bone mineral accretion in boys but not girls but no increased risk for osteopenia.
conclusionsMultiple oral corticosteroid bursts over a period of years can produce a dosage-dependent reduction in bone mineral accretion and increased risk for osteopenia in children with asthma. Inhaled corticosteroid use has the potential for reducing bone mineral accretion in male children progressing through puberty, but this risk is likely to be outweighed by the ability to reduce the amount of oral corticosteroids used in these children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.