ArticleProceedings of the National Academy of Sciences of the United States of America2008
Detrimental effects of Bartonella henselae are counteracted by L-arginine and nitric oxide in human endothelial progenitor cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Antibiotic Susceptibility of Bartonella Grown in Different Culture Conditions.Pathogens (Basel, Switzerland) · 2021Article
- What Is in a Cat Scratch? Growth ofMicroorganisms · 2021Review
- Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis.Clinical microbiology reviews · 2017Review
- Novel Approach for Evaluation ofFrontiers in microbiology · 2016Article
- Apolipoprotein A-I mimetic peptide D-4F promotes human endothelial progenitor cell proliferation, migration, adhesion though eNOS/NO pathway.Molecular biology reports · 2012Article
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Bartonella infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation.Clinical & developmental immunology · 2012Review
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- Article
- Impairment of circulating endothelial progenitors in Down syndrome.BMC medical genomics · 2010Article
- An immunocompromised murine model of chronic Bartonella infection.The American journal of pathology · 2010Article
- A censored beta mixture model for the estimation of the proportion of non-differentially expressed genes.Bioinformatics (Oxford, England) · 2010Article
- The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway.American journal of physiology. Cell physiology · 2009Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recruitment of circulating endothelial progenitor cells (EPCs) might have a beneficial effect on the clinical course of several diseases. Endothelial damage and detachment of endothelial cells are known to occur in infection, tissue ischemia, and sepsis. These detrimental effects in EPCs are unknown. Here we elucidated whether human EPCs internalize Bartonella henselae constituting a circulating niche of the pathogen. B. henselae invades EPCs as shown by gentamicin protection assays and transmission electron microscopy (TEM). Dil-Ac-LDL/lectin double immunostaining and fluorescence-activated cell sorting (FACS) analysis of EPCs revealed EPC bioactivity after infection with B. henselae. Nitric oxide (NO) and its precursor l-arginine (l-arg) exert a plethora of beneficial effects on vascular function and modulation of immune response. Therefore, we tested also the hypothesis that l-arg (1-30 mM) would affect the infection of B. henselae or tumor necrosis factor (TNF) in EPCs. Our data provide evidence that l-arg counteracts detrimental effects induced by TNF or Bartonella infections via NO (confirmed by DETA-NO and L-NMMA experiments) and by modulation of p38 kinase phosphorylation. Microarray analysis indicated several genes involved in immune response were differentially expressed in Bartonella-infected EPCs, whereas these genes returned in steady state when cells were exposed to sustained doses of l-arg. This mechanism may have broad therapeutic applications in tissue ischemia, angiogenesis, immune response, and sepsis.
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