Evidence map›Paper›PMID 18595780›Full record

ArticleAutonomic neuroscience : basic & clinical2008

Postnatal expression of corticotropin releasing factor (CRF) in rat urinary bladder.

Jennifer LaBerge, Susan E Malley, Beatrice Girard, Kimberly Corrow, Margaret A Vizzard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autonomic neuroscience : basic & clinical, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer LaBergeDepartment of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Susan E MalleyDepartment of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Beatrice GirardDepartment of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA; Department of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Kimberly CorrowDepartment of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Margaret A VizzardDepartment of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA; Department of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA; Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA. Electronic address: margaret.vizzard@uvm.edu.
University of Vermont · US

Funding

Cystitis-Induced Plasticity of Micturition ReflexesR01DK051369 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2003 to 2017
$5.4M
Developmental Plasticity of Micturition ReflexesR01DK060481 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2002 to 2018
$4.5M
Neurotrophic Mechanisms in LUT Plasticity with CystitisR01DK065989 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2003 to 2007
$1.4M
Developmental plasticity of micturation reflexesR56DK060481 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2008 to 2008
$232k
IRRITATION INDUCED PLASTICITY OF MICTURITION PATHWAYSR29DK051369 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 1996 to 2000
$109k
NIDDK NIH HHS DK051369NIDDK NIH HHS DK060481NIDDK NIH HHS DK065989NIDDK NIH HHS R01 DK051369NIDDK NIH HHS R01 DK060481NIDDK NIH HHS R01 DK065989NIDDK NIH HHS R29 DK051369NIDDK NIH HHS R56 DK060481
6 · The paper itself

Abstract

Corticotropin releasing factor (CRF) is a neuropeptide expressed in micturition reflex circuitry and different roles in these reflexes have been suggested. These studies examined the expression of CRF/CRF receptors in the urinary bladder during postnatal development in the rat. Urinary bladder was harvested from rats (postnatal (P) day 0-adult) euthanized by isoflurane (4%) and thoracotomy. CRF protein expression significantly (p<or=0.01) decreased in the urothelium with increasing postnatal age. In contrast, CRF-immunoreactivity (IR) was increased in nerve fibers in the suburothelial plexus during the second-third postnatal week. Total CRF protein from urinary bladder significantly increased during the second-third postnatal weeks as determined with ELISAs. CRF receptor 2 (CRFR(2)) transcript was expressed in urinary bladder of all postnatal ages examined whereas no CRFR(1) transcript was expressed at any postnatal age examined. We also demonstrated changes in urinary bladder mRNA expression for the neuropeptides, galanin, substance P, vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide during postnatal development. These studies demonstrate changes in the CRF expression in urinary bladder, specifically in the urothelium and nerve fibers of the suburothelial plexus during postnatal development. Changes in CRF expression and neuropeptide expression in general in the urinary bladder may contribute to the emergence of mature voiding reflexes.

Indexed as

Age FactorsAnimalsCorticotropin-Releasing HormoneEnzyme-Linked Immunosorbent AssayFemaleGalaninGene ExpressionImmunohistochemistryMaleNerve FibersNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptideRatsRats, WistarReceptors, Corticotropin-Releasing HormoneReverse Transcriptase Polymerase Chain ReactionCorticotropin-Releasing HormoneCRF receptor type 2GalaninNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Corticotropin-Releasing HormoneRNA, MessengerSubstance PVasoactive Intestinal Peptide

Identifiers

PMID18595780
PMCPMC2569849
OpenAlexW2081116551

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.