ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2008
Increased heart rate variability but normal resting metabolic rate in hypocretin/orexin-deficient human narcolepsy.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.Sleep medicine reviews · 2020Pooled it
- Autonomic function classification and sleep quality among young adults in Central Java, Indonesia: A cluster analysis.Preventive medicine reports · 2025Article
- Autonomic cardiovascular control is unaffected in children referred for assessment of excessive daytime sleepiness.Journal of sleep research · 2025Article
- Comorbidity of obstructive sleep apnea and narcolepsy: A challenging diagnosis and complex management.Sleep medicine: X · 2024Review
- Orexin receptor antagonist increases fat oxidation and suppresses protein catabolism during sleep in humans.iScience · 2024Article
- Body Weight and Metabolic Rate Changes in Narcolepsy: Current Knowledge and Future Directions.Metabolites · 2022Review
- Metabolic-Syndrome-Related Comorbidities in Narcolepsy Spectrum Disorders: A Preliminary Cross-Sectional Study in Japan.International journal of environmental research and public health · 2022Article
- Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022Review
- Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).Neuropsychiatric disease and treatment · 2022Article
- Autonomic symptoms, cardiovascular and sudomotor evaluation in de novo type 1 narcolepsy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Narcolepsy with cataplexy: Does age at diagnosis change the clinical picture?CNS neuroscience & therapeutics · 2020Article
- Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1.Frontiers in endocrinology · 2020Review
- Decreased body mass index during treatment with sodium oxybate in narcolepsy type 1.Journal of sleep research · 2019Article
- The neurobiological basis of narcolepsy.Nature reviews. Neuroscience · 2019Review
- A 10-Year Longitudinal Observational Study Of Cataplexy In A Cohort Of Narcolepsy Type 1 Patients.Nature and science of sleep · 2019Article
- Autonomic regulation during sleep and wakefulness: a review with implications for defining the pathophysiology of neurological disorders.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- The effects of intensified training on resting metabolic rate (RMR), body composition and performance in trained cyclists.PloS one · 2018Article
- Challenges in the development of therapeutics for narcolepsy.Progress in neurobiology · 2017Review
- Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance.Journal of neurochemistry · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesWe investigated autonomic balance and resting metabolic rate to explore their possible involvement in obesity in hypocretin/orexin-deficient narcoleptic subjects.
methodsResting metabolic rate (using indirect calorimetry) and variability in heart rate and blood pressure were determined in the fasted resting state. Subjects included 15 untreated, hypocretin-deficient male narcoleptics and 15 male controls matched for age and body mass index.
resultsSpectral power analysis revealed greater heart rate and blood pressure variability in hypocretin-deficient male narcoleptic patients (heart rate: p = 0.01; systolic blood pressure: p = 0.02; diastolic: p < 0.01). The low to high frequency ratio of heart rate power did not differ between groups (p = 0.48), nor did resting metabolic rate (controls: 1767 +/- 226 kcal/24 h; patients: 1766 +/- 227 kcal/24h; p = 0.99).
conclusionsResting metabolic rate was not reduced in hypocretin-deficient narcoleptic men and therefore does not explain obesity in this group. Whether the increased heart rate and blood pressure variability--suggesting reduced sympathetic tone--is involved in this regard remains to be elucidated.
Indexed as
Identifiers
18595438PMC2546458W2142422187What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.