ArticleDigestive diseases and sciences2009
Disease behavior in children with Crohn's disease: the effect of disease duration, ethnicity, genotype, and phenotype.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Prognostic biomarkers to identify patients likely to develop severe Crohn's disease: a systematic review.Health technology assessment (Winchester, England) · 2021Pooled it
- Expert consensus on diagnostic guidelines for pediatric inflammatory bowel disease in Japan.Journal of gastroenterology · 2025Review
- Review on Advances in Pediatric Endoscopy in the Management of Inflammatory Bowel Disease.Current pediatric reviews · 2025Review
- Predicting complications in pediatric Crohn's disease patients followed in CEDATA-GPGE registry.Frontiers in pediatrics · 2023Article
- Endoscopic balloon dilation for management of stricturing Crohn's disease in children.World journal of gastrointestinal endoscopy · 2021Article
- Inflammatory Bowel Disease in the Baby to Baby Boomer: Pediatric and Elderly Onset of IBD.Current treatment options in gastroenterology · 2018Review
- Higher Morbidity of Monogenic Inflammatory Bowel Disease Compared to the Adolescent Onset Inflammatory Bowel Disease.Pediatric gastroenterology, hepatology & nutrition · 2018Article
- Clinical and Phenotypic Differences in Inflammatory Bowel Disease Among Arab and Jewish Children in Israel.Digestive diseases and sciences · 2017Article
- High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults.PloS one · 2017Article
- Crohn's Strictures-Moving Away from the Knife.Frontiers in pediatrics · 2017Review
- Ashkenazi Jewish origin protects against formation of antibodies to infliximab and therapy failure.Medicine · 2015Article
- Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review.World journal of gastroenterology · 2014Article
- Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.Journal of human genetics · 2014Article
- Immune phenotype in children with therapy-naïve remitted and relapsed Crohn's disease.World journal of gastroenterology · 2010Article
- Peyer's Patches: The Immune Sensors of the Intestine.International journal of inflammation · 2010Article
- Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients.Inflammatory bowel diseases · 2010Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisease behavior in Crohn's disease (CD) may be modified by disease location and genotype. Disease behavior may change over time, and thus analysis requires follow-up. To date, there have been few pediatric studies that have evaluated the association between disease behavior and genotype with prolonged follow-up. The aim of our study was to evaluate the effect of genotype, phenotype, and ethnicity on disease behavior in pediatric CD.
methodsEvaluation of 128 pediatric CD was followed by analysis of 232 pediatric and adult-onset CD patients. Inclusion required at least 2 years of follow-up. Phenotype, ethnicity, and disease duration were recorded. Patients were genotyped for polymorphisms in the NOD2/CARD15 gene.
resultsColonic involvement was more frequent in younger patients. Pediatric disease at end of follow-up was classified as inflammatory (78%), penetrating (7%), and stricturing (17%). Duration of follow-up (mean 4.9 pediatric and 6.4 years mixed) was associated with more stricturing and penetrating disease. There was no association between mean age of onset and NOD2/CARD15, or either of these with disease behavior. These observations were replicated in the mixed cohort. Sephardic Jewish origin was inversely correlated with inflammatory behavior (P = 0.006), independent of NOD2/CARD15 genotype.
conclusionsDuration of disease and ethnicity, irrespective of NOD2/CARD15 genotype and age of onset, were the only predictors for penetrating or stricturing disease.
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