Evidence map›Paper›PMID 18594919›Full record

ArticleSurgical endoscopy2008

The use of porcine small intestinal submucosa as a prosthetic material for laparoscopic hernia repair in infected and potentially contaminated fields: long-term follow-up.

Morris E Franklin, Jorge M Treviño, Guillermo Portillo, Itzel Vela, Jeffrey L Glass, John J González

Registry-linked trialAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03702153 (The Use of Synthetic Mesh in Contaminated and Infected Abdominal Wall Repairs), which is not on this map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03702153 nacompletednot on this mapstarted 2012, after this paper: background citation

The Use of Synthetic Mesh in Contaminated and Infected Abdominal Wall Repairs: Challenging the Dogma of an Absolute Contra-indication. A Long-term Prospective Clinical Trial

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2012 to 2018Enrolled80ConditionsAbdominal Wall Defect, Abdominal Wall Infection, Abdominal Wall Fistula, InfectionArmsAbdominal wall reconstruction
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Repair of parastomal hernias with biologic grafts: a systematic review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011
    Pooled it
  5. Biosynthetic graft versus autologous graft tympanoplasty: a prospective randomized controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Trial
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  12. Review
  13. Review
  14. Review
  15. Article
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  19. Article
  20. Evaluation of a Novel Absorbable Mesh in a Porcine Model of Abdominal Wall Repair.Plastic and reconstructive surgery. Global open · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Morris E FranklinTexas Endosurgery Institute, 4242 East Southcross Boulevard, Suite 1, San Antonio, TX 78222, USA.
Jorge M Treviño
Guillermo Portillo
Itzel Vela
Jeffrey L Glass
John J González
Texas Endosurgery Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe treatment of hernias remains controversial, with multiple prosthetic meshes being exalted for a variety of their characteristics. In the event of incarcerated/strangulated hernias and other potentially contaminated fields the placement of prosthetic material remains controversial because of increased risk of recurrence and infection. Porcine small intestinal submucosa mesh (Surgisis, Cook Bloomington, IN) has been demonstrated safe and feasible in laparoscopic hernia repairs in this scenario. We present our 5-year experience, with placement of Surgisis mesh in potentially or grossly contaminated fields.

methodsFrom May 2000 to October 2006, 116 patients (52 male, 64 female) with 133 procedures were performed. Placement of Surgisis mesh for either incisional, umbilical, inguinal, femoral or parastomal hernia repairs in an infected or potentially contaminated setting were achieved, and studied in a prospective fashion.

resultsAll procedures were laparoscopically with two techniques [intraperitoneal onlay mesh (IPOM) and two-layered "sandwich" repair]. Mean follow-up was 52 +/- 20.9 months. Thirty-nine cases were in an infected field and the rest in a potentially contaminated field. Ninety-one procedures were performed concurrently with a contaminated procedure. Twenty-five presented as intestinal obstruction, 16 strangulated hernias, and 17 required small bowel resection; 29 were inguinal hernias, 57 incisional, and 38 umbilical. In 13 patients more than two different hernias were repaired. Eighty-five percent 5-year follow-up was achieved, during which we identified 7 recurrences, 11 seromas (all resolved), and 10 patients reporting mild pain. Six second looks were performed and in all cases except one the mesh was found to be totally integrated into the tissue with strong scar tissue corroborated macro- and microscopically.

conclusionsIn our experience the use of small intestine submucosa mesh in contaminated or potentially contaminated fields is a safe and feasible alternative to hernia repair with minimal recurrence rate and satisfactory results in long-term follow-up.

Indexed as

BioprosthesisHerniorrhaphyIntestinal MucosaLaparoscopySurgical MeshSurgical Wound InfectionAbsorbable ImplantsAdultAgedAged, 80 and overAnimalsFemaleFollow-Up StudiesHumansIntestine, SmallMale

Identifiers

PMID18594919
OpenAlexW1999298099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.