ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2008
Serological microarray for a paradoxical diagnostic of Whipple's disease.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Whipple's disease presenting as weight gain and constipation in a Chinese woman.BMC infectious diseases · 2023Article
- Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei.PloS one · 2019Article
- Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.Clinical microbiology reviews · 2017Review
- Deglycosylation of Tropheryma whipplei biofilm and discrepancies between diagnostic results during Whipple's disease progression.Scientific reports · 2016Article
- Whipple's Disease.Viszeralmedizin · 2014Review
- Serologic prevalence of amoeba-associated microorganisms in intensive care unit pneumonia patients.PloS one · 2013Article
- Intrafamilial circulation of Tropheryma whipplei, France.Emerging infectious diseases · 2012Article
- Changing paradigms in Whipple's disease and infection with Tropheryma whipplei.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Review
- An experimental mouse model to establish Tropheryma whipplei as a diarrheal agent.The Journal of infectious diseases · 2011Article
- Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease.Infection and immunity · 2010Article
- Tropheryma whipplei in patients with pneumonia.Emerging infectious diseases · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whipple's disease is a systemic chronic infection caused by Tropheryma whipplei. Asymptomatic people may carry T. whipplei in their digestive tract and this can be determined by PCR, making serological diagnosis useful to distinguish between carriers and patients. Putative antigenic proteins were selected by computational analysis of the T. whipplei genome, immunoproteomics studies and from literature. After expression, putative T. whipplei antigens were screened by microimmunofluorescence with sera of immunized rabbit. Selected targets were screened by microarray using sera from patients and carriers. Paradoxically, with 19 tested recombinant proteins and a glycosylated native protein of T. whipplei, a higher immune response was observed with asymptomatic carriers. In contrast, quantification of human IgA exhibited a higher reaction in patients than in carriers against 10 antigens. These results were used to design a diagnostic test with a cut-off value for each antigen. A blind test assay was performed and was able to diagnose 6/8 patients and 11/12 carriers. Among people with positive T. whipplei PCR of the stool, patients differ from carriers by having positive IgA detection and a negative IgG detection. If confirmed, this serological test will distinguish between carriers and patients in people with positive PCR of the stool.
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