ArticleInternational journal of colorectal disease2008
The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer.
Article in International journal of colorectal disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer.The journal of pathology. Clinical research · 2025Article
- Non-canonical approaches to targeting hypoxic tumors.American journal of cancer research · 2022Review
- Prolyl 4-hydroxylase alpha 1 protein expression risk-stratifies early stage colorectal cancer.Oncotarget · 2020Article
- Correlation and expression analysis of hypoxia-inducible factor 1α, glucose transporter 1 and lactate dehydrogenase 5 in human gastric cancer.Oncology letters · 2019Article
- Review
- Article
- Retracted Article: Down-regulation of Rab10 inhibits hypoxia-induced invasion and EMT in thyroid cancer cells by targeting HIF-1α through the PI3K/Akt pathway.RSC advances · 2018Article
- Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells.OncoTargets and therapy · 2016Article
- Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells.American journal of cancer research · 2015Article
- Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response.The British journal of radiology · 2014Review
- Regional differences in prostaglandin E₂ metabolism in human colorectal cancer liver metastases.BMC cancer · 2013Article
- Antagonistic crosstalk between APC and HIF-1α.Cell cycle (Georgetown, Tex.) · 2011Article
- Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.Molecular biology of the cell · 2010Article
- Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.British journal of cancer · 2010Article
- Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goalsTumour hypoxia has been shown to be a predictor of early distant relapse in node-negative breast and cervical cancer. The purpose of the present study was to determine the role of hypoxia in predicting patients who are at high risk of disease recurrence in Dukes B colorectal cancers. MATERIALS AND
methodsArchival tissue was retrieved from 52 patients who had undergone surgical resection for primary colorectal cancer. Tissue micro-arrays were constructed using tissue from the margin and the centre of the tumour. Hypoxia markers hypoxia-inducible factor (Hif)-1 alpha, vascular endothelial growth factor (VEGF), carbonic anhydrase (CA)-9 and glucose transporter (Glut)-1 were visualised using immunohistochemical detection and quantified using semi-quantitative analysis of the digitised images. Clinical details and outcome data were retrieved by case note review and collated with hypoxia markers data in a statistical database.
resultsPrimary colorectal cancers with a high Hif-1 alpha expression tended to have a significantly worse disease-free survival (log rank p < 0.001) and overall survival (log rank p = 0.012). VEGF was also a significant predictor of disease recurrence in primary colorectal cancers (p = 0.015). Significant correlations were also noted between Hif-1 alpha and VEGF (Pearson's p = 0.009). Glut-1 and CA-9 did not show a similar pattern with no differences in the expression pattern and no correlation observed with any of the markers. Multivariate analysis of prognostic factors showed vascular invasion (p < 0.001) and Hif-1 alpha at the tumour margin (p < 0.001) to be independent predictors for the development of liver metastases.
conclusionThese results suggest an important role for Hif-1 alpha and VEGF in colorectal cancer progression, with both markers biological mechanisms directly interlinked through the hypoxic pathway. Identification of high-risk patients using the above factors will improve treatment strategies in node-negative disease and help improve patient outcome.
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