ArticleJournal of neural transmission (Vienna, Austria : 1996)2008
L-dopa modulates motor cortex excitability in Alzheimer's disease patients.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of transcranial magnetic stimulation studies.Ageing research reviews · 2022Pooled it
- Noninvasive brain stimulation in Alzheimer's disease: systematic review and perspectives for the future.Experimental gerontology · 2011Pooled it
- Contribution of Glutamatergic and GABAergic Mechanisms to the Plasticity-Modulating Effects of Dopamine in the Human Motor Cortex.Human brain mapping · 2025Trial
- A model for de novo pigmentation of amelanotic retinal pigment epithelial cells.Acta ophthalmologica · 2026Article
- Versatility of Transcranial Magnetic Stimulation: A Review of Diagnostic and Therapeutic Applications.Brain sciences · 2026Review
- Transcranial magnetic stimulation from healthy brain aging to Alzheimer's disease: a review on mechanisms, therapeutic potential, and future clinical directions.Frontiers in aging neuroscience · 2026Review
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients.Annals of neurology · 2023Article
- The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders.Frontiers in psychiatry · 2022Review
- Transcranial Magnetic Stimulation as a Diagnostic and Therapeutic Tool in Various Types of Dementia.Journal of clinical medicine · 2021Review
- Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Catecholamine-Based Treatment in AD Patients: Expectations and Delusions.Frontiers in aging neuroscience · 2015Review
- Dopamine differently modulates central cholinergic circuits in patients with Alzheimer disease and CADASIL.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study.PloS one · 2013Article
- CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.CNS & neurological disorders drug targets · 2012Review
- Intra- and inter-cortical motor excitability in Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Transcranial magnetic stimulation in Alzheimer's disease: a neurophysiological marker of cortical hyperexcitability.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease.International journal of Alzheimer's disease · 2011Article
- Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?CNS neuroscience & therapeutics · 2010Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Alzheimer's disease (AD), transcranial magnetic stimulation (TMS) studies have shown abnormalities of motor cortical excitability, such as a decreased intra-cortical inhibition (ICI) and changes in resting motor threshold (rMT). We studied the effects of L-dopa on rMT and ICI in a cohort of moderate AD patients after paired-pulse TMS. Results were compared with a control group of healthy subjects. As expected, AD patients showed a significant reduction in ICI and a lower rMT. L-dopa administration (soluble form, melevodopa 200 mg) promptly reversed the ICI impairment up to normalization. This effect was specific, since it was not mimicked in control subjects. These results indicate a possible role of dopamine in modulating AD cortical excitability, thus suggesting an interaction between dopaminergic ascending pathways and endogenous intracortical transmitters. In addition, considering that L-dopa showed a pharmacological profile similar to the one of cholinomimetics, L-dopa might represent a reliable tool to study new therapeutic perspective and strategies for AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.