ArticleJournal of lipid research2008
A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands.
Article in Journal of lipid research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A stop-gain variant inHGG advances · 2023Pooled it
- Using Community Based Research Frameworks to Develop and Implement a Church-Based Program to Prevent Diabetes and Its Complications for Samoan Communities in South Western Sydney.International journal of environmental research and public health · 2021Article
- Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.Journal of human genetics · 2021Article
- A missense variant in CREBRF is associated with taller stature in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2020Article
- Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia.Scientific reports · 2015Article
- Overweight condition and waist circumference and a candidate gene within the 12q24 locus.Cardiovascular diabetology · 2013Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders.Epigenetics · 2011Article
- First assessment of menstrual cycle function and reproductive endocrine status in Samoan women.Human reproduction (Oxford, England) · 2011Article
- Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.Journal of lipid research · 2011Article
- A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1.European journal of human genetics : EJHG · 2010Article
- PRELIMINARY BLOOD LIPID, LIPOPROTEIN AND GLUCOSE FINDINGS FROM THE GENOME-WIDE ASSOCIATION STUDY OF ADIPOSITY IN SAMOANS.Samoa medical journal · 2010Article
- Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs.BMC genetics · 2010Article
- Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.BMC medical genetics · 2009Article
- Dietary patterns are associated with metabolic syndrome in adult Samoans.The Journal of nutrition · 2009Article
- Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Adiponectin and type 2 diabetes in Samoan adults.American journal of human biology : the official journal of the Human Biology CouncilArticle
- Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study.American journal of human biology : the official journal of the Human Biology CouncilArticle
- Translating the semi-structured assessment for drug dependence and alcoholism in the Western Pacific: rationale, study design and reliability of alcohol dependence.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Abnormal lipid levels are important risk factors for cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing total cholesterol (TC), LDL, HDL and triglyceride in families residing in American Samoa and Samoa as well as in a combined sample from the two polities. We adjusted the traits for a number of environmental covariates, such as smoking, alcohol consumption, physical activity, and material lifestyle. We found suggestive univariate linkage with log of the odds (LOD) scores > 3 for LDL on 6p21-p12 (LOD 3.13) in Samoa and on 12q21-q23 (LOD 3.07) in American Samoa. Furthermore, in American Samoa on 12q21, we detected genome-wide linkage (LOD(eq) 3.38) to the bivariate trait TC-LDL. Telomeric of this region, on 12q24, we found suggestive bivariate linkage to TC-HDL (LOD(eq) 3.22) in the combined study sample. In addition, we detected suggestive univariate linkage (LOD 1.9-2.93) on chromosomes 4p-q, 6p, 7q, 9q, 11q, 12q 13q, 15q, 16p, 18q, 19p, 19q and Xq23 and suggestive bivariate linkage (LOD(eq) 2.05-2.62) on chromosomes 6p, 7q, 12p, 12q, and 19p-q. In conclusion, chromosome 6p and 12q may host promising susceptibility loci influencing lipid levels; however, the low degree of overlap between the three study samples strongly encourages further studies of the lipid-related traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.