ArticleClinical cancer research : an official journal of the American Association for Cancer Research2008
Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 93 citations in OpenAlex.
- Identification of Gene Signatures Differentiating Cancer from Normal Tissues Across Histological Classifications of Gastric Adenocarcinoma via Machine Learning Methods.Biochemical genetics · 2026Article
- The emerging roles of ITM2A: At the molecular crossroads of development and pathogenesis.iScience · 2026Review
- Research progress on exosomal proteins as diagnostic markers of gastric cancer (review article).Clinical and experimental medicine · 2023Review
- Ubiquitination of ADRα1d/SerpinA1 complex stimulates hypoxia to induce gastric tumorigenesis with a combination of Helicobacter pylori and chronic stress through IL-1α.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Article
- Low-level gastrokine 2 promoted progress of NSCLC and as a potential biomarker.Journal of clinical laboratory analysis · 2022Article
- Immunoexpression of Trefoil Factor 1 in Non-Neoplastic and Neoplastic Canine Gastric Tissues.Animals : an open access journal from MDPI · 2021Article
- Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity.Scientific reports · 2021Article
- Gastrokine 2 Regulates the Antitumor Effect of JAK2/STAT3 Pathway in Gastric Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Trefoil factor 1 and gastrokine 2 inhibitOncology letters · 2020Article
- Review
- Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Induction and Prevention of Gastric Cancer with CombinedCancers · 2020Article
- Multiscale network analysis reveals molecular mechanisms and key regulators of the tumor microenvironment in gastric cancer.International journal of cancer · 2020Article
- Prognostic Value of Gastrokine-2 (GKN2) and Its Correlation with Tumor-Infiltrating Immune Cells in Lung Cancer and Gastric Cancers.Journal of inflammation research · 2020Article
- Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy.Beilstein journal of nanotechnology · 2020Article
- The role and diagnostic potential of gastrokine 1 in gastric cancer.Cancer management and research · 2019Review
- Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.Gastroenterology and hepatology from bed to bench · 2018Article
- Dysbindin promotes progression of pancreatic ductal adenocarcinoma via direct activation of PI3K.Journal of molecular cell biology · 2017Article
- Global transcriptome‑wide analysis of the function of GDDR in acute gastric lesions.Molecular medicine reports · 2017Article
- Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Article
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
purposeTranscriptional profiling showed decreased expression of gastrokine 1 (GKN1) and the related trefoil factor interacting protein (TFIZ1/GKN2) in Helicobacter pylori infection. Decreased GKN1 and GKN2 mRNA expression has been reported in gastric adenocarcinoma. We have examined GKN1 and GKN2 protein expression in a large gastric cancer series, correlated expression with tumor subtype, and evaluated their utility as prognostic biomarkers. EXPERIMENTAL
designGKN1, GKN2, and the trefoil factors TFF1 and TFF3 were examined in tissue microarrays from 155 distal gastric adenocarcinomas. Immunohistochemical expression was correlated with clinical outcome. GKN1 and GKN2 expression was measured by real-time PCR and Western analysis in samples of gastric cancer and adjacent nonneoplastic mucosa.
resultsGKN1 was lost in 78% of diffuse and 42% of intestinal cancers (P < 0.0001, diffuse versus intestinal). GKN2 expression was lost in 85% of diffuse and 54% of intestinal type cancers (P < 0.002). GKN1 and GKN2 down-regulation were confirmed by Western and real-time PCR analysis. Loss of either protein was associated with significantly worse outcome in intestinal-type tumors by univariate analysis; and GKN2 loss remained a predictor of poor outcome in multivariate analysis (P < 0.033). TFF1 was lost in >70%, and TFF3 was expressed in approximately 50% of gastric cancers.
conclusionsLoss of GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype. GKN1 and GKN2 loss are associated with shorter overall survival in the intestinal subtype.
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