ArticlePhysiological genomics2008
Involvement of T1R3 in calcium-magnesium taste.
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
- Taste coding of heavy metal ion-induced avoidance iniScience · 2023Article
- Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors.Microorganisms · 2023Review
- Oral expressions and functional analyses of the extracellular calcium-sensing receptor (CaSR) in chicken.Scientific reports · 2022Article
- Understanding the evolution of nutritive taste in animals: Insights from biological stoichiometry and nutritional geometry.Ecology and evolution · 2021Review
- Metal Ions Activate the Human Taste Receptor TAS2R7.Chemical senses · 2019Article
- CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.Neuron · 2018Article
- The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.International journal of molecular sciences · 2018Review
- Taste receptors in the upper airway.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.The Journal of biological chemistry · 2017Article
- Phosphorus Taste Involves T1R2 and T1R3.Chemical senses · 2017Article
- Maltodextrin Acceptance and Preference in Eight Mouse Strains.Chemical senses · 2016Article
- Multiple loss-of-function variants of taste receptors in modern humans.Scientific reports · 2015Article
- Heightened avidity for trisodium pyrophosphate in mice lacking Tas1r3.Chemical senses · 2015Article
- Taste receptors in innate immunity.Cellular and molecular life sciences : CMLS · 2015Review
- Macronutrient selection by seven inbred mouse strains and three taste-related knockout strains.Physiology & behavior · 2014Article
- Peripheral coding of taste.Neuron · 2014Review
- Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium and magnesium are essential for survival but it is unknown how animals detect and consume enough of these minerals to meet their needs. To investigate this, we exploited the PWK/PhJ (PWK) strain of mice, which, in contrast to the C57BL/6J (B6) and other inbred strains, displays strong preferences for calcium solutions. We found that the PWK strain also has strong preferences for MgCl2 and saccharin solutions but not representative salty, sour, bitter, or umami taste compounds. A genome scan of B6 x PWK F2 mice linked a component of the strain difference in calcium and magnesium preference to distal chromosome 4. The taste receptor gene, Tas1r3, was implicated by studies with 129.B6ByJ-Tas1r3 congenic and Tas1r3 knockout mice. Most notably, calcium and magnesium solutions that were avoided by wild-type B6 mice were preferred (relative to water) by B6 mice null for the Tas1r3 gene. Oral calcium elicited less electrophysiological activity in the chorda tympani nerve of Tas1r3 knockout than wild-type mice. Comparison of the sequence of Tas1r3 with calcium and saccharin preferences in inbred mouse strains found 1) an inverse correlation between calcium and saccharin preference scores across primarily domesticus strains, which was associated with an I60T substitution in T1R3, and 2) a V689A substitution in T1R3 that was unique to the PWK strain and thus may be responsible for its strong calcium and magnesium preference. Our results imply that, in addition to its established roles in the detection of sweet and umami compounds, T1R3 functions as a gustatory calcium-magnesium receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.