ArticleGenome research2008
DNA methylation and heterochromatinization in the male-specific region of the primitive Y chromosome of papaya.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 130 citations in OpenAlex.
- Sex chromosome pairing and multivalent associations during meiosis in diploid and polyploid Silene latifolia.Plant physiology · 2026Article
- Recreating viable YYNature communications · 2026Article
- Assembly and analysis of Sinipercidae fish sex chromosomes reveals that a supergene drives sex chromosome origin and turnover.Advanced biotechnology · 2025Article
- Appearance of transient heteromorphic large chromosome in glyphosate-resistant Amaranthus tuberculatus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Article
- The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- New Insights on Chromosome Diversification in Malagasy Chameleons.Animals : an open access journal from MDPI · 2024Article
- Carica papaya L. sex chromosome review and physical mapping of the serk 2, svp-like and mdar 4 sequences.Scientific reports · 2024Article
- Sex-specific DNA methylation: impact on human health and development.Molecular genetics and genomics : MGG · 2022Review
- Identification of an Epigenetically Marked Locus within the Sex Determination Region of Channel Catfish.International journal of molecular sciences · 2022Article
- Development and applications of a collection of single copy gene-based cytogenetic DNA markers in garden asparagus.Frontiers in plant science · 2022Article
- DNA methylation is involved in sexual differentiation and sex chromosome evolution in the dioecious plant garden asparagus.Horticulture research · 2021Article
- Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair.Genome biology · 2021Article
- Transcriptional regulation of dosage compensation in Carica papaya.Scientific reports · 2021Article
- Divergence and Remarkable Diversity of the Y Chromosome in Guppies.Molecular biology and evolution · 2021Article
- The Role of Structural Maintenance of Chromosomes Complexes in Meiosis and Genome Maintenance: Translating Biomedical and Model Plant Research Into Crop Breeding Opportunities.Frontiers in plant science · 2021Review
- Establishment and evolution of heterochromatin.Annals of the New York Academy of Sciences · 2020Review
- Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion.BMC biology · 2020Article
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
- DNA methylome and transcriptome landscapes revealed differential characteristics of dioecious flowers in papaya.Horticulture research · 2020Article
- Fine mapping of the sex locus inHorticulture research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex chromosomes evolved from autosomes. Recombination suppression in the sex-determining region and accumulation of deleterious mutations lead to degeneration of the Y chromosomes in many species with heteromorphic X/Y chromosomes. However, how the recombination suppressed domain expands from the sex-determining locus to the entire Y chromosome remains elusive. The Y chromosome of papaya (Carica papaya) diverged from the X chromosome approximately 2-3 million years ago and represents one of the most recently emerged Y chromosomes. Here, we report that the male-specific region of the Y chromosome (MSY) spans approximately 13% of the papaya Y chromosome. Interestingly, the centromere of the Y chromosome is embedded in the MSY. The centromeric domain within the MSY has accumulated significantly more DNA than the corresponding X chromosomal domain, which leads to abnormal chromosome pairing. We observed four knob-like heterochromatin structures specific to the MSY. Fluorescence in situ hybridization and immunofluorescence assay revealed that the DNA sequences associated with the heterochromatic knobs are highly divergent and heavily methylated compared with the sequences in the corresponding X chromosomal domains. These results suggest that DNA methylation and heterochromatinization play an important role in the early stage of sex chromosome evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.