ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2008
Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Review
- A mathematical model of hiPSC cardiomyocytes electromechanics.Physiological reports · 2021Article
- Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the NaWiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Transmural cellular heterogeneity in myocardial electromechanics.The journal of physiological sciences : JPS · 2018Article
- A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.Frontiers in physiology · 2018Review
- Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study.BioMed research international · 2018Article
- Evaluation of a Novel Finite Element Model of Active Contraction in the Heart.Frontiers in physiology · 2018Article
- Organ-level validation of a cross-bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains.Physiological reports · 2017Article
- Study of the union method of microelectrode array and AFM for the recording of electromechanical activities in living cardiomyocytes.European biophysics journal : EBJ · 2017Article
- Regional effects of streptozotocin-induced diabetes on shortening and calcium transport in epicardial and endocardial myocytes from rat left ventricle.Physiological reports · 2016Article
- Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.Annals of biomedical engineering · 2016Article
- Biomechanics of Cardiac Function.Comprehensive Physiology · 2015Review
- The cardiac muscle duplex as a method to study myocardial heterogeneity.Progress in biophysics and molecular biology · 2014Review
- Article
- An analysis of deformation-dependent electromechanical coupling in the mouse heart.The Journal of physiology · 2012Article
- At the heart of computational modelling.The Journal of physiology · 2012Review
- Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study.American journal of physiology. Heart and circulatory physiology · 2012Article
- Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Journal of the Royal Society, Interface · 2011Review
- Imaging the electromechanical activity of the heart in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cardiac models in drug discovery and development: a review.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation-contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterogeneous electromechanical behaviour in these cells. The simulations (i) illustrate a previously unrecognized role of the transient outward potassium current in mechanical function and (ii) suggest that there may also exist additional heterogeneities affecting crossbridge cycling rates in cells from different transmural regions.
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