ReviewInternational wound journal2008
Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation.
Review in International wound journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06242379 (Safety and Efficacy Evaluation of Intravitreal Injection of GMP-compliant Bone Marrow Mesenchymal Stem Cell-derived Small Extracellular Vesicles in Patients With Retinitis Pigmentosa), which is not on this map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy Evaluation of Intravitreal Injection of GMP-compliant Bone Marrow Mesenchymal Stem Cell-derived Small Extracellular Vesicles in Patients With Retinitis Pigmentosa
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 217 citations in OpenAlex.
- RCT-based meta-analysis of povidone-iodine irrigation in spinal surgery: clarifying efficacy and safety.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- Pooled it
- Surgical hand antisepsis to reduce surgical site infection.The Cochrane database of systematic reviews · 2016Pooled it
- Long-term Impact of Intravitreal Injections on the ocular surface; a 2-year follow-up study.Frontiers in ophthalmology · 2026Trial
- Effectiveness of betadine-coating gastrostomy tube to reduce peristomal infection after percutaneous endoscopic gastrostomy: a randomized controlled trial.BMC gastroenterology · 2023Trial
- Tolerability and effectiveness of povidone-iodine or mupirocin versus saline sinus irrigations for chronic rhinosinusitis.American journal of otolaryngologyTrial
- Octenidine-Based Versus Chlorhexidine-Based Preoperative Skin Antisepsis in Primary Hip and Knee Arthroplasty.Arthroplasty today · 2026Article
- Chitosan Nanofibrous Dressing Increased Angiogenesis and Anti-inflammatory Response in an Acute Wound Model in Rats: A Comparative Study.Annals of biomedical engineering · 2025Article
- Development of Paclitaxel Injection Concentrate for Nanodispersion.AAPS PharmSciTech · 2025Article
- Preventing Surgical Site Infections: A Narrative Review of Antiseptic Solutions in the Operating Theatre.Cureus · 2025Review
- Review
- Concentration of Povidone-Iodine Pocket Irrigation in Implant-Based Breast Surgery: A Scoping Review.Aesthetic plastic surgery · 2025Article
- Reviewing the complexities of bacterial biocide susceptibility and in vitro biocide adaptation methodologies.npj antimicrobials and resistance · 2025Review
- Biocides as drivers of antibiotic resistance: A critical review of environmental implications and public health risks.Environmental science and ecotechnology · 2025Review
- Injectable iodine-containing peptide hydrogel for treatment of MRSA infection.Bioactive materials · 2025Article
- The Role of Lactic Acid in Episiotomy Wound Healing: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Article
- Surgical Site Preparation Using Alcohol with Chlorhexidine Compared with Povidone Iodine with Chlorhexidine Results in Similar Rate of Infection After Primary Total Joint Arthroplasty.Antibiotics (Basel, Switzerland) · 2025Article
- Topical Povidone Iodine 2.5% Versus 5% for Endophthalmitis Prophylaxis During Intravitreal Injections.Journal of ophthalmology · 2025Article
- Field study on routine procedures for navel care in neonatal calves on dairy farms in Eastern Germany.PloS one · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iodine and its antibacterial properties have been used for the prevention or management of wound infections for over 150 years. However, the use of solutions (tincture) of iodine has been replaced by the widespread use of povidone-iodine, a water-soluble compound, which is a combination of molecular iodine and polyvinylpyrrolidone. The resultant broad spectrum of antimicrobial activity is well documented and its efficacy, particularly in relation to resistant micro-organisms such as methicillin-resistant Staphylococcus aureus, has been shown. In the clinical environment, there is no general agreement regarding the 'best' antiseptic and the practice varies widely. This article reviews the studies that have assessed the efficacy of povidone-iodine in hand disinfection and skin preparation and its use as an antiseptic irrigant. Although there is a distinct lack of well-designed, randomised controlled trials evaluating antiseptic efficacy, selection should be based on the next best available evidence. This evidence suggests that the use of povidone-iodine as an agent of choice is dependent on the clinical need but is also likely to be influenced by personal preference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.