ArticleJournal of clinical immunology2008
Mannose-binding lectin MBL2 gene polymorphisms and outcome of hepatitis C virus-infected patients.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Plasma proteins as potential biomarkers of aging of single tissue and cell type.Biogerontology · 2024Article
- Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children.Molecular biology reports · 2023Article
- Polymorphisms in theFrontiers in immunology · 2023Article
- Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.Cellular and molecular gastroenterology and hepatology · 2022Article
- Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection.Frontiers in immunology · 2020Article
- The role of mannose binding lectin on fever episodes in pediatric oncology patients.Pathology oncology research : POR · 2016Article
- MBL-associated serine proteases (MASPs) and infectious diseases.Molecular immunology · 2015Review
- The roles of direct recognition by animal lectins in antiviral immunity and viral pathogenesis.Molecules (Basel, Switzerland) · 2015Review
- Human lectins and their roles in viral infections.Molecules (Basel, Switzerland) · 2015Review
- Article
- Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa.G3 (Bethesda, Md.) · 2013Article
- Review
- MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection.Human immunology · 2011Article
- Article
- Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.Protein & cell · 2010Article
- Mannose-binding lectin gene polymorphism and chronic hepatitis B infection in children.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMannose-binding lectin (MBL) is involved in host's response to several infections including hepatitis B but little is known about MBL and hepatitis C virus (HCV) infection. The present study attempts to investigate whether MBL2 genotype and serum MBL levels affect the course of HCV infection. RESULTS AND DISCUSSIONS: We investigated the variant alleles in MBL2 gene promoter and exon-1 regions in 80 Caucasian HCV-infected patients. Mutations in MBL2 were determined by polymerase chain reaction and restriction fragment length polymorphisms analysis. Serum MBL levels were measured by ELISA. Polymorphism homozygosity in exon-1 region was significantly related to lower serum MBL levels (p < 0.001), to liver inflammation (p = 0.034, OR = 11.7) and, in a lesser degree, to fibrosis. Polymorphisms in promoter sites -221nt and -550nt were not shown to be related with serum MBL levels or progress to liver inflammation and fibrosis. Serum MBL levels were adversely associated with progression to fibrosis (p = 0.037). Response to antiviral treatment was related to hepatitis C virus genotype (p < 0.001, OR = 10.9), but not to MBL2 genotype or serum MBL levels.
conclusionThese findings suggest that polymorphisms in MBL2 gene exon-1 region are related to low serum MBL levels and progression of HCV infection to liver inflammation and fibrosis.
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Registered trials
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