ArticleLipids2008
Metabolic syndrome affects fatty acid composition of plasma lipids in obese prepubertal children.
Article in Lipids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes.Scientific reports · 2023Article
- Differential Association of Dietary Linoleic Acid and Alpha-linolenic Acid with Adipose Tissue in a Sample of Iranian Adults; A Cohort-based Cross-sectional Study.Galen medical journal · 2023Article
- Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats.GeroScience · 2021Article
- Article
- Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples.Journal of food and drug analysis · 2020Review
- Serum Polyunsaturated Fatty Acids in Middle Childhood and Body Mass Index Change Through Adolescence.Annals of nutrition & metabolism · 2019Article
- Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity.Nutrients · 2018Article
- Article
- Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link?International journal of molecular sciences · 2015Review
- Alpha-linolenic acid (ALA) is inversely related to development of adiposity in school-age children.European journal of clinical nutrition · 2015Article
- Article
- A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals.PloS one · 2014Article
- Structural and compositional changes in erythrocyte membrane of obese compared to normal-weight adolescents.The Journal of membrane biology · 2013Article
- A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids.European journal of clinical nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to assess the plasma fatty acid composition of the total plasma lipids and lipid fractions in obese prepubertal children with and without metabolic syndrome (MS). Thirty-four obese prepubertal children were recruited: 17 who met MS criteria and 17 who did not; and twenty prepubertal children of normal weight. MS characteristics, insulin resistance (by homeostasis model assessment [HOMA-IR]), and plasma adiponectin (by radioimmunoassay) were recorded. Separation of lipid fractions was performed by liquid chromatography and the concentration of fatty acids in total plasma lipids and fractions was determined by gas-liquid chromatography. Concentrations of 16:1n-7, 16:1n-9, 18:3n-3, 22:6n-3, and n-3 PUFA in total plasma lipids (P < 0.05) and of 16:0, 16:1n-7, 18:1n-9, 18:2n-6, and n-6 PUFA in triacylglycerols (TG) (P < 0.05) were significantly higher in obese MS versus normal-weight children. Increased risk of MS was positively associated with plasma concentration of 16:1n-7 and negatively associated with proportion of 20:4n-6 (OR 2.76; P = 0.004; OR 0.56, P = 0.030, respectively). Saturated FA in TG were associated with HOMA-IR (R = 0.349, P = 0.017) and 22:5n-6 with adiponectin (R = 0.336, P = 0.05). In conclusion, increased concentrations of 16:1n-7 and decreased proportions of 20:4n-6 and 22:5n-6 in plasma lipids appear to be early markers of MS in children at prepubertal age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.