ArticleRheumatology international2008
Prevalence and risk factors of osteoporosis in patients with Parkinson's disease.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Pooled it
- Bone health in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2014Pooled it
- Bone mineral density and vitamin D status in Parkinson's disease patients.Journal of neurology · 2013Trial
- Beyond the Brain: Exploring the multi-organ axes in Parkinson's disease pathogenesis.Journal of advanced research · 2026Review
- Bone involvement in the early stages of Parkinson's disease: a case-control study.The Journal of international medical research · 2024Article
- Osteoporosis in Parkinson's disease and the role of lean body mass: a cross-sectional study in a Brazilian tertiary center.Frontiers in endocrinology · 2024Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- The Dashboard Vitals of Parkinson's: Not to Be Missed Yet an Unmet Need.Journal of personalized medicine · 2022Article
- Low skull bone density is associated with poor motor prognosis in women with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Understanding the role ofFrontiers in pharmacology · 2022Review
- The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.Translational neurodegeneration · 2020Review
- The outcome for surgical fixation of distal radial fractures in patients with idiopathic Parkinson's disease: a cohort study.Journal of orthopaedic surgery and research · 2020Article
- Effects of Neurological Disorders on Bone Health.Frontiers in psychology · 2020Review
- The fate of thoracolumbar surgeries in patients with Parkinson's disease, and analysis of risk factors for revision surgeries.BMC musculoskeletal disorders · 2019Article
- Fragility Fractures and Parkinsonism: Relationship of Fractures with Demography, Severity and Predictors of Adverse Outcomes.Geriatrics (Basel, Switzerland) · 2017Article
- Progression of postural changes in Parkinson's disease: quantitative assessment.Journal of neurology · 2017Article
- Comorbid Parkinson's disease, falls and fractures in the 2010 National Emergency Department Sample.Parkinsonism & related disorders · 2017Article
- Risk Factors, Epidemiology and Treatment Strategies for Metabolic Bone Disease in Patients with Neurological Disease.Current osteoporosis reports · 2016Review
- Comparing the Incidence of Falls/Fractures in Parkinson's Disease Patients in the US Population.PloS one · 2016Article
- Musculoskeletal problems in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is the most common cause of disability in the elderly. It is currently recognized as a cause of secondary osteoporosis. To evaluate the prevalence of osteoporosis in PD and detect its risk factors, 52 patients with PD (36 men/16 women) and 52 controls paired for age and sex were recruited. Clinical data including demography, disease duration and disease severity were collected. All subjects had bone mineral density (BMD) measured by dual energy X-ray absorptiometry, dorsal and lumbar spine X-ray, and biological exams (osteocalcin, CTX, parathormon). The mean age of the patients was 60.0 +/- 9.25 years [30-77], and the mean disease duration was 4.9 +/- 4.5 years [0.2-17]. Nine patients (17.3%) were osteoporotic and 28 (53.8%) osteopenic. BMD at the lumbar spine and the hip was lower among patients than controls (spine: 1.031 vs. 1.175 g/cm(2); P < 0.001; hip: 0.968 vs. 1.054; P = 0.02). PD patients with low BMD presented a more severe disease and an insufficient sun exposure and calcium intake. There was a positive statistically significant correlation between patients BMD and body mass index and negative correlation with age, severity of PD, and osteocalcin levels. The prevalence of osteoporosis/osteopenia is high in PD patients and seems related to the severity of the disease, an insufficient sun exposure and calcium intake. This osteoporosis constitutes with falls the major risk factors of fracture in PD patients.
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