ArticleDiabetologia2008
Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.Diabetologia · 2021Trial
- Preventable Prenatal and Neonatal Risk Factors of Type 1 Diabetes in Childhood.International journal of preventive medicine · 2023Article
- Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Bayesian Joint Modeling of Multivariate Longitudinal and Survival Data With an Application to Diabetes Study.Frontiers in big data · 2022Article
- Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.Diabetologia · 2021Article
- Article
- Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort.Scandinavian journal of gastroenterology · 2020Article
- Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study.Diabetes care · 2020Article
- Decreased HLA-DQ expression on peripheral blood cells in children with varying number of beta cell autoantibodies.Journal of translational autoimmunity · 2020Article
- Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies.Journal of autoimmunity · 2018Article
- Article
- Metabolomic Biomarkers in the Progression to Type 1 Diabetes.Current diabetes reports · 2016Review
- Article
- Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype.European journal of epidemiology · 2015Article
- Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.International journal of obesity (2005) · 2014Article
- Article
- The environment and the origins of islet autoimmunity and Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2013Review
- On the etiology of type 1 diabetes: a new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response.The American journal of pathology · 2012Article
- Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden.International journal of obesity (2005) · 2012Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
aims/hypothesisHigh birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH).
methodsBirthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study.
resultsBirth length SDS corrected for MPH was increased in children developing diabetes compared with all (p < 0.048) and with non-HLA- (p < 0.050) but not with HLA-matched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p < 0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. CONCLUSIONS/
interpretationBirth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA- but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA- and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes.
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