ArticleMedical molecular morphology2008
Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor.
Article in Medical molecular morphology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hybrid sclerosing adenosis and basal cell hyperplasia of the prostate.Medical molecular morphology · 2010Article
- Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities.BMC gastroenterology · 2010Article
- Immunohistochemical application of D2-40 as basal cell marker in evaluating atypical small acinar proliferation of initial routine prostatic needle biopsy materials.Medical molecular morphology · 2010Article
- Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells.Medical molecular morphology · 2009Article
- Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.Medical molecular morphology · 2009Article
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Authors and funding
10 authors.
Funding
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Abstract
We incidentally found the expression of D2-40 in Cajal interstitial cells for the immunohistochemical valuation of lymphatic invasion by gastric and colonic cancer cells. Therefore, we suggested that D2-40 might become an available marker for gastrointestinal stromal tumors (GISTs). In this study, we performed immunohistochemical study of 21 GISTs, As a result, we confirmed a positive reaction for D2-40 in sixteen GISTs. Among sixteen tumors, thirteen tumors were focally positive and remaining three tumors were diffusely positive. We could find no relationship between positive findings for D2-40 and size or location of the tumor. Three of four tumors with intermediate risk of aggressive behavior and two of four tumors with recurrence showed a negative reaction for D2-40. In conclusion, we suggest that D2-40 may be an available marker of GISTs, but the expression of D2-40 seems to be not associated with the degree of risk of aggressive behavior.
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