ArticleJournal of neuro-oncology2008
Primary T-cell CNS lymphoma presenting with leptomeningeal spread and neurolymphomatosis.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Primary central nervous system T cell lymphoma involving multiple brain and spinal cord lesions with SETD2 mutation.International journal of hematology · 2026Article
- The natural history of neurolymphomatosis.BJC reports · 2024Article
- Neurolymphomatosis in Recrudescent Diffuse Large B-cell Lymphoma.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Review
- Peripheral T-Cell Lymphomas Involving the Central Nervous System: A Report From the Czech Lymphoma Study Group Registry.Frontiers in oncology · 2022Article
- Systemic ALK-positive anaplastic large cell lymphoma with bilateral optic neurolymphomatosis resulting in permanent blindness.Clinical case reports · 2020Article
- Recurrence of nasal type NK/T cell lymphoma presenting as neurolymphomatosis on 18F-FDG PET/CT: A case report and literature review.Medicine · 2020Review
- Diagnostic delay in a case of T-cell neurolymphomatosis.BMJ case reports · 2019Article
- B-cell peripheral neurolymphomatosis: MRI andSkeletal radiology · 2019Article
- Neurolymphomatosis in non-Hodgkin lymphoma with cranial multineuritis: A case report.Medicine · 2018Article
- Primary Central Nervous System Anaplastic Large T-cell Lymphoma.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.The American journal of surgical pathology · 2015Article
- Neuropathies associated with lymphomaNeuro-oncology practice · 2015Review
- Primary T cell central nervous system lymphoblastic lymphoma in a child: case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report.Journal of neurological surgery reports · 2014Article
- Isolated Recurrence of Diffuse Large B-Cell Lymphoma in Sciatic Nerve.World journal of oncology · 2014Article
- Cerebral venocclusive disease due to CNS T cell lymphoma.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- (18)F-FDG PET/CT in Neurolymphomatosis: Report of 3 Cases.Asia Oceania journal of nuclear medicine & biology · 2014Article
- Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report.Neurology · 2013Article
- A case of cranial multinevritis: from the onset to the diagnosis of primary neurolymphomatosis.BMJ case reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary CNS lymphoma (PCNSL), a rare form of non-Hodgkin lymphoma that is confined to the brain, is usually of B-cell origin. Primary leptomeningeal lymphoma, regardless of T or B-cell origin, is an unusual site of presentation. Out of 100 consecutive PCNSL patients that we have followed up in our center during the last 10 years, five had T-cell lymphoma (5%). All presented with leptomeningeal involvement as the sole manifestation and four of them presented with neuronal lymphomatosis. Presenting symptoms included signs of elevated intracranial pressure with 6th nerve palsy; headache and bilateral 3rd nerve palsy; mononeuritis multiplex and unilateral hearing loss; bilateral 7th nerve paralysis and bilateral uveitis. Because neither the CSF nor the MRI were indicative, meningeal or nerve biopsies were required for conclusive diagnosis. Four patients died 10-19 months from disease onset and one patient is alive 36 months following the diagnosis. We conclude that T-cell PCNSL can present as an isolated leptomeningeal involvement which may be associated with neurolymphomatosis affecting cranial and peripheral nerves. These manifestations mimic other neurological conditions such as pseudotumor cerebri or vasculitis. Diagnosis is difficult and, as a result, frequently delayed. This calls for early consideration of meningeal or nerve biopsy whenever CSF findings are inconclusive.
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