ReviewJournal of psychiatry & neuroscience : JPN2008
Reproductive hormone sensitivity and risk for depression across the female life cycle: a continuum of vulnerability?
Review in Journal of psychiatry & neuroscience : JPN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Efficacy and safety of non-hormonal pharmacotherapies for depressive and anxiety symptoms during the menopausal transition and postmenopause: a systematic review.BMC psychiatry · 2026Pooled it
- A systematic review of associations between hormone levels in hair and peripartum depression.Psychoneuroendocrinology · 2025Pooled it
- Prevalence and associated factors of depression in postmenopausal women: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Premenstrual exacerbation of mental health disorders: a systematic review of prospective studies.Archives of women's mental health · 2022Pooled it
- Association between premenstrual dysphoric disorder and perinatal depression: a systematic review.Archives of women's mental health · 2022Pooled it
- Addictive behaviors across the menstrual cycle: a systematic review.Archives of women's mental health · 2021Pooled it
- Global burden of antenatal depression and its association with adverse birth outcomes: an umbrella review.BMC public health · 2020Pooled it
- Women Undergoing Hormonal Treatments for Infertility: A Systematic Review on Psychopathology and Newly Diagnosed Mood and Psychotic Disorders.Frontiers in psychiatry · 2020Pooled it
- Pooled it
- A systematic review of the prevalence and risk factors of depression among iranian adolescents.Global journal of health science · 2013Pooled it
- Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.Journal of healthcare engineering · 2023Trial
- Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder.Journal of psychiatric research · 2017Trial
- Changes in sleep quality, but not hormones predict time to postpartum depression recurrence.Journal of affective disorders · 2011Trial
- Reproductive health - a blind spot in psychotherapeutic treatment? Evidence of insufficient consideration of reproductive factors in routine care.Dialogues in clinical neuroscience · 2026Article
- The impact of mental health disorders in pregnancy on obstetric and neonatal outcomes: A narrative review.Brain, behavior, & immunity - health · 2026Review
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- Intensity and exposure proximity as determinants of differential stress-related health outcomes.Molecular psychiatry · 2026Observational
- Depression in mothers at four weeks and twenty-four weeks postpartum: a study on the prevalence and selected risk factors in Sri Lanka.BMC pregnancy and childbirth · 2026Article
- Global, regional, and national burden of depression among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021.Archives of women's mental health · 2026Article
- Osteoarthritis and depression a bidirectional TwoSample Mendelian randomization study on genetic causal association.BMC musculoskeletal disorders · 2026Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Throughout most of their lives, women are at greater risk for depression than men. Hormones and neurotransmitters share common pathways and receptor sites in areas of the brain linked to mood, particularly through the hypothalamic-pituitary-gonadal axis. It has been hypothesized that women presenting with episodes of depression associated with reproductive events (i.e., premenstrual, postpartum, menopausal transition) may be particularly prone to experiencing depression, in part because of a heightened sensitivity to intense hormonal fluctuations. The menopausal transition, for example, appears to represent a window during which some women might be more vulnerable to the development of first onset or recurrent depressive symptoms and major depressive episodes. In this review, we examine the association between hormone changes and increased risk of developing depression. Some of the underlying mechanisms that may contribute to such an increased risk are discussed critically, with a special emphasis on the events occurring during the menopausal transition. Last, we explore some of the clinical and therapeutic implications of hormone-modulated depression in women.
Indexed as
Identifiers
18592034PMC2440795What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.