ReviewJournal of psychiatry & neuroscience : JPN2008
Sex steroid-related candidate genes in psychiatric disorders.
Review in Journal of psychiatry & neuroscience : JPN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Females in Psychedelic Research: A Perspective for Advancing Research and Practice.ACS pharmacology & translational science · 2025Review
- Respite time-use among dementia caregivers.Frontiers in health services · 2025Article
- Non-Synonymous Substitutions in Cadherin 13, Solute Carrier Family 6 Member 4, and Monoamine Oxidase A Genes are Associated with Personality Traits in Thoroughbred Horses.Behavior genetics · 2024Article
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
- Understanding the Interplay Between Premenstrual Dysphoric Disorder (PMDD) and Female Sexual Dysfunction (FSD).Cureus · 2024Review
- Women's health, hormonal balance, and personal autonomy.Frontiers in medicine · 2023Review
- Identifying the Factors That Affect Depressive Symptoms in Middle-Aged Menopausal Women: A Nationwide Study in Korea.International journal of environmental research and public health · 2020Article
- Normal Testosterone but Higher Luteinizing Hormone Plasma Levels in Men With Hypersexual Disorder.Sexual medicine · 2020Article
- Sex Differences in Cue Competition Effects With a Conditioned Taste Aversion Preparation.Frontiers in behavioral neuroscience · 2020Article
- Depression and Its Association with Health-Related Quality of Life in Postmenopausal Women in Korea.International journal of environmental research and public health · 2018Article
- Serum levels of GPER-1 in euthymic bipolar patients.Neuropsychiatric disease and treatment · 2018Article
- Increased Serum G Protein-coupled Estrogen Receptor 1 Levels and Its Diagnostic Value in Drug Naïve Patients with Major Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Reproductive Affective Disorders: a Review of the Genetic Evidence for Premenstrual Dysphoric Disorder and Postpartum Depression.Current psychiatry reports · 2017Review
- The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study.Social psychiatry and psychiatric epidemiology · 2015Article
- From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases.World journal of stem cells · 2015Review
- GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner.Hormones and behavior · 2014Article
- Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.Molecular psychiatry · 2014Article
- Common variants in psychiatric risk genes predict brain structure at birth.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Minireview: translational animal models of human menopause: challenges and emerging opportunities.Endocrinology · 2012Review
- Genetic determinants of aggression and impulsivity in humans.Journal of applied genetics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex steroids readily pass the blood-brain barrier, and receptors for them are abundant in brain areas important for the regulation of emotions, cognition and behaviour. Animal experiments have revealed both important early effects of these hormones on brain development and their ongoing influence on brain morphology and neurotransmission in the adult organism. The important effects of sex steroids on human behaviour are illustrated by, for example, the effect of reduced levels of these hormones on sexual drive and conditions such as premenstrual dysphoric disorder, perimenopausal dysphoria, postpartum depression, postpartum psychosis, dysphoria induced by oral contraceptives or hormonal replacement therapy and anabolic steroid-induced aggression. The fact that men and women (as groups) differ with respect to the prevalence of several psychiatric disorders, certain aspects of cognitive function and certain personality traits may possibly also reflect an influence of sex steroids on human behaviour. The heritability of most behavioural traits, including personality, cognitive abilities and susceptibility to psychiatric illness, is considerable, but as yet, only few genes of definite importance in this context have been identified. Given the important role of sex steroids for brain function, it is unfortunate that relatively few studies so far have addressed the possible influence of sex steroid-related genes on interindividual differences with respect to personality, cognition and susceptibility to psychiatric disorders. To facilitate further research in this area, this review provides information on several such genes and summarizes what is currently known with respect to their possible influence on brain function.
Indexed as
Identifiers
18592033PMC2440794W1867720809What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.