ArticleDrug discovery today. Disease models2007
Models of reactive oxygen species in cancer.
Article in Drug discovery today. Disease models, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
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- P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology.Journal of cardiovascular development and disease · 2022Article
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- Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.Cell death & disease · 2021Article
- Isaria tenuipes Peck, an entomopathogenic fungus from Darjeeling Himalaya: Evaluation of in-vitro antiproliferative and antioxidant potential of its mycelium extract.BMC complementary medicine and therapies · 2020Article
- Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.Pathology oncology research : POR · 2020Article
- Elucidation of Biochemical Pathways Underlying VOCs Production in A549 Cells.Frontiers in molecular biosciences · 2020Article
- Bioenergetics of life, disease and death phenomena.Theory in biosciences = Theorie in den Biowissenschaften · 2018Article
- Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection.Molecular and cellular biochemistry · 2017Article
- Metformin reduces the expression of NADPH oxidase and increases the expression of antioxidative enzymes in human monocytes/macrophages culturedExperimental and therapeutic medicine · 2016Article
- Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells.PloS one · 2016Article
- Evaluating the anticancer properties of liposomal copper in a nude xenograft mouse model of human prostate cancer: formulation, in vitro, in vivo, histology and tissue distribution studies.Pharmaceutical research · 2014Article
- SOD2 to SOD1 switch in breast cancer.The Journal of biological chemistry · 2014Article
- Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium.PloS one · 2014Article
- Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.Breast cancer research : BCR · 2013Article
- Targeting cancer cell mitochondria as a therapeutic approach.Future medicinal chemistry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Increased generation of reactive oxygen species (ROS) has been observed in cancer, degenerative diseases, and other pathological conditions. ROS can stimulate cell proliferation, promote genetic instability, and induce adaptive responses that enable cancer cells to maintain their malignant phenotypes. However, when cellular redox balance is severely disturbed, high levels of ROS may cause various damages leading to cell death. The studies of ROS effects on biological systems, their underlying mechanisms and therapeutic implications largely depend on proper experimental models. Here we review several in vitro and in vivo models for ROS research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.