ArticleCirculation2008
Transcriptomic biomarkers for individual risk assessment in new-onset heart failure.
Article in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Rationale and design of the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy (the POSEIDON-DCM study): a phase I/II, randomized pilot study of the comparative safety and efficacy of transendocardial injection of autologous mesenchymal stem cell vs. allogeneic mesenchymal stem cells in patients with non-ischemic dilated cardiomyopathy.Journal of cardiovascular translational research · 2014Trial
- Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.JACC. Advances · 2024Article
- Mesenchymal STRO-1/STRO-3Future cardiology · 2023Review
- Long-term prognostic value of myocardin expression levels in non-ischemic dilated cardiomyopathy.Heart and vessels · 2021Article
- DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.American journal of physiology. Heart and circulatory physiology · 2019Article
- Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis: Current Developments and Future Prospects.Frontiers in microbiology · 2019Review
- Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy.Genomics, proteomics & bioinformatics · 2016Article
- Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy.JACC. Basic to translational science · 2016Review
- Gene Expression Signatures and the Spectrum of Coronary Artery Disease.Journal of cardiovascular translational research · 2015Review
- Epigenetics of the failing heart.Heart failure reviews · 2015Review
- Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure.Genome medicine · 2015Article
- Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction.Journal of molecular and cellular cardiology · 2014Article
- Ribonucleic acid biomarkers for heart failure is there a correlation between heart and blood transcriptomics?JACC. Heart failure · 2013Article
- Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy.European heart journal · 2013Article
- Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension.Pulmonary circulation · 2013Article
- Molecular signatures and the study of gene expression profiles in inflammatory heart diseases.Herz · 2012Review
- Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy.Molecular medicine (Cambridge, Mass.) · 2012Article
- Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics.Clinical chemistry · 2012Review
- Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction.BMC medical genomics · 2011Article
- Distinct epigenomic features in end-stage failing human hearts.Circulation · 2011Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrediction of prognosis remains a major unmet need in new-onset heart failure (HF). Although several clinical tests are in use, none accurately distinguish between patients with poor versus excellent survival. We hypothesized that a transcriptomic signature, generated from a single endomyocardial biopsy, could serve as a novel prognostic biomarker in HF. METHODS AND
resultsEndomyocardial biopsy samples and clinical data were collected from all patients presenting with new-onset HF from 1997 to 2006. Among a total of 350 endomyocardial biopsy samples, 180 were identified as idiopathic dilated cardiomyopathy. Patients with phenotypic extremes in survival were selected: good prognosis (event-free survival for at least 5 years; n=25) and poor prognosis (events [death, requirement for left ventricular assist device, or cardiac transplant] within the first 2 years of presentation with HF symptoms; n=18). We used human U133 Plus 2.0 microarrays (Affymetrix) and analyzed the data with significance analysis of microarrays and prediction analysis of microarrays. We identified 46 overexpressed genes in patients with good versus poor prognosis, of which 45 genes were selected by prediction analysis of microarrays for prediction of prognosis in a train set (n=29) with subsequent validation in test sets (n=14 each). The biomarker performed with 74% sensitivity (95% CI 69% to 79%) and 90% specificity (95% CI 87% to 93%) after 50 random partitions.
conclusionsThese findings suggest the potential of transcriptomic biomarkers to predict prognosis in patients with new-onset HF from a single endomyocardial biopsy sample. In addition, our findings offer potential novel therapeutic targets for HF and cardiomyopathy.
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