ArticleDiabetes2008
Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Neuronatin Influences Endothelial Homeostasis and Atherosclerosis via ER-Mitochondria Interactions.Journal of inflammation research · 2026Article
- Ciwujianoside C Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis via NNAT-Mediated Inhibition of NF-κB Signaling.Neurochemical research · 2025Article
- Paradoxical SERCA2a Dysregulation Contributes to Atrial Fibrillation in a Model of Diet-Induced Obesity.International journal of molecular sciences · 2025Article
- Exercise in Diabetic Cardiomyopathy: Its Protective Effects and Molecular Mechanism.International journal of molecular sciences · 2025Review
- Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies.Discover oncology · 2024Article
- Article
- Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats.Biology of sex differences · 2024Article
- Neuronatin Promotes the Progression of Non-small Cell Lung Cancer by Activating the NF-κB Signaling.Current cancer drug targets · 2024Article
- Circulating Neuronatin Levels Are Positively Associated with BMI and Body Fat Mass but Not with Psychological Parameters.Nutrients · 2023Article
- Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.Scientific reports · 2021Article
- The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer.Cancer biomarkers : section A of Disease markers · 2021Article
- Transcriptomics Curation of SARS-CoV-2 Related Host Genes in Mice With COVID-19 Comorbidity: A Pilot Study.Infectious microbes & diseases · 2020Article
- Characteristic Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- PPARMediators of inflammation · 2019Article
- Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance.Journal of cardiovascular translational research · 2018Article
- High neuronatin (NNAT) expression is associated with poor outcome in breast cancer.Virchows Archiv : an international journal of pathology · 2017Article
- Neuronatin is a stress-responsive protein of rod photoreceptors.Neuroscience · 2016Article
- Article
- Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.Cardiovascular diabetology · 2015Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIdentification of arterial genes and pathways altered in obesity and diabetes. RESEARCH DESIGN AND
methodsAortic gene expression profiles of obese and diabetic db/db, high-fat diet-fed C57BL/6J, and control mice were obtained using mouse Affymetrix arrays. Neuronatin (Nnat) was selected for further analysis. To determine the function of Nnat, a recombinant adenovirus (Ad-Nnat) was used to overexpress the Nnat gene in primary endothelial cells and in the mouse aorta in vivo.
resultsNnat, a gene of unknown vascular function, was upregulated in the aortas of db/db and high-fat diet-fed mice. Nnat gene expression was increased in db/db mouse aorta endothelial cells. Nnat protein was localized to aortic endothelium and was selectively increased in the endothelium of db/db mice. Infection of primary human aortic endothelial cells (HAECs) with Ad-Nnat increased expression of a panel of nuclear factor-kappaB (NF-kappaB)-regulated genes, including inflammatory cytokines, chemokines, and cell adhesion molecules. Infection of mouse carotid arteries in vivo with the Ad-Nnat increased expression of vascular cell adhesion molecule 1 protein. Nnat activation of NF-kappaB and inflammatory gene expression in HAECs was mediated through pathways distinct from tumor necrosis factor-alpha. Nnat expression stimulated p38, Jun NH(2)-terminal kinase, extracellular signal-related kinase, and AKT kinase phosphorylation. Phosphatidylinositol 3-kinase and p38 inhibitors prevented Nnat-mediated activation of NF-kappaB-induced gene expression.
conclusionsNnat expression is increased in endothelial cells of obese and diabetic mouse blood vessels. The effects of Nnat on inflammatory pathways in vitro and in vivo suggest a pathophysiological role of this new gene in diabetic vascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.