ArticleThe Plant cell2008
Mutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.Frontiers in cell and developmental biology · 2026Review
- Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq).bioRxiv : the preprint server for biology · 2025Article
- Integrated transcriptomic and metabolic analyses reveal the early response mechanism of Pinus tabulaeformis to pine wood nematodes.BMC genomics · 2024Article
- The peptidase DA1 cleaves and destabilizes WUSCHEL to control shoot apical meristem size.Nature communications · 2024Article
- The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective.Frontiers in plant science · 2022Article
- Analysis of BRCT5 domain-containing proteins reveals a new component of DNA damage repair in Arabidopsis.Frontiers in plant science · 2022Article
- Regulation of Shoot Apical Meristem and Axillary Meristem Development in Plants.International journal of molecular sciences · 2020Review
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- Article
- Regulation of Division and Differentiation of Plant Stem Cells.Annual review of cell and developmental biology · 2018Review
- A Gossypium hirsutum GDSL lipase/hydrolase gene (GhGLIP) appears to be involved in promoting seed growth in Arabidopsis.PloS one · 2018Article
- Cytokinin Signaling ActivatesThe Plant cell · 2017Article
- Two-Step Functional Innovation of the Stem-Cell Factors WUS/WOX5 during Plant Evolution.Molecular biology and evolution · 2017Article
- A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.Plant physiology · 2016Article
- RNA Binding Proteins RZ-1B and RZ-1C Play Critical Roles in Regulating Pre-mRNA Splicing and Gene Expression during Development in Arabidopsis.The Plant cell · 2016Article
- The never-ending story: from pluripotency to plant developmental plasticity.Development (Cambridge, England) · 2015Review
- ALTERED MERISTEM PROGRAM1 suppresses ectopic stem cell niche formation in the shoot apical meristem in a largely cytokinin-independent manner.Plant physiology · 2015Article
- ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.Nature communications · 2015Article
- Plant hormone signaling and modulation of DNA repair under stressful conditions.Plant cell reports · 2013Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Stem cell fate in the Arabidopsis thaliana shoot apical meristem (SAM) is controlled by WUSCHEL (WUS) and CLAVATA. Here, we examine BARD1 (for BRCA1-associated RING domain 1), which had previously been implicated in DNA repair functions; we find that it also regulates WUS expression. We observed severe SAM defects in the knockout mutant bard1-3. WUS transcripts accumulated >238-fold in bard1-3 compared with the wild type and were located mainly in the outermost cell layers instead of the usual organizing center. A specific WUS promoter region was recognized by nuclear protein extracts obtained from wild-type plants, and this protein-DNA complex was recognized by antibodies against BARD1. The double mutant (wus-1 bard1-3) showed prematurely terminated SAM structures identical to those of wus-1, indicating that BARD1 functions through regulation of WUS. BARD1 overexpression resulted in reduced WUS transcript levels, giving a wus-1-like phenotype. Either full-length BARD1 or a clone that encoded the C-terminal domain (BARD1:C-ter;bard1-3) was sufficient to complement the bard1-3 phenotype, indicating that BARD1 functions through its C-terminal domain. Our data suggest that BARD1 regulates SAM organization and maintenance by limiting WUS expression to the organizing center.
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