Evidence map›Paper›PMID 18591271›Full record

ArticleAntimicrobial agents and chemotherapy2008

Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.

Lili Rosana Mesak, Vivian Miao, Julian Davies

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
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  7. The Multifaceted Actions of PVP-Curcumin for Treating Infections.International journal of molecular sciences · 2024
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  8. Review
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  10. NaturalizedFrontiers in microbiology · 2022
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  11. Review
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  14. A How-To Guide for Mode of Action Analysis of Antimicrobial Peptides.Frontiers in cellular and infection microbiology · 2020
    Review
  15. Article
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  17. RexAB is essential for the mutagenic repair ofAntimicrobial agents and chemotherapy · 2019
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lili Rosana MesakDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada. mesak@interchange.ubc.ca
Vivian Miao
Julian Davies
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.

Indexed as

Gene Expression Regulation, BacterialAnti-Bacterial AgentsArabidopsis ProteinsBacterial ProteinsDNA Mismatch RepairDNA RepairDrug Resistance, BacterialFluoroquinolonesHumansMicrobial Sensitivity TestsPromoter Regions, GeneticRecombinant Fusion ProteinsSOS Response, GeneticsStaphylococcus aureusTranscription FactorsAnti-Bacterial AgentsArabidopsis ProteinsBacterial ProteinsFluoroquinolonesLux Arrhythmo protein, ArabidopsisRecombinant Fusion ProteinsTranscription Factors

Identifiers

PMID18591271
PMCPMC2533449
OpenAlexW2097566310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.