ArticleMolecular and cellular biology2008
Cyclin-specific control of ribosomal DNA segregation.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Meiosis in budding yeast.Genetics · 2023Article
- The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator.International journal of molecular sciences · 2022Review
- The role of Rif1 in telomere length regulation is separable from its role in origin firing.eLife · 2020Article
- Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.Current biology : CB · 2017Article
- Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis.EMBO molecular medicine · 2016Article
- Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.The Journal of cell biology · 2014Article
- Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.Journal of cell science · 2014Article
- The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.Genetics · 2014Article
- The C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage.Biology open · 2013Article
- Sequential primed kinases create a damage-responsive phosphodegron on Eco1.Nature structural & molecular biology · 2013Article
- Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.Genetics · 2012Article
- Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles.Journal of the Royal Society, Interface · 2011Article
- Dynamics of Cdk1 substrate specificity during the cell cycle.Molecular cell · 2011Article
- Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.The Journal of biological chemistry · 2010Article
- The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.The Journal of cell biology · 2010Article
- Article
- Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Following chromosome duplication in S phase of the cell cycle, the sister chromatids are linked by cohesin. At the onset of anaphase, separase cleaves cohesin and thereby initiates sister chromatid separation. Separase activation results from the destruction of its inhibitor, securin, which is triggered by a ubiquitin ligase called the anaphase-promoting complex (APC). Here, we show in budding yeast that securin destruction and, thus, separase activation are not sufficient for the efficient segregation of the repetitive ribosomal DNA (rDNA). We find that rDNA segregation also requires the APC-mediated destruction of the S-phase cyclin Clb5, an activator of the protein kinase Cdk1. Mutations that prevent Clb5 destruction are lethal and cause defects in rDNA segregation and DNA synthesis. These defects are distinct from the mitotic-exit defects caused by stabilization of the mitotic cyclin Clb2, emphasizing the importance of cyclin specificity in the regulation of late-mitotic events. Efficient rDNA segregation, both in mitosis and meiosis, also requires APC-dependent destruction of Dbf4, an activator of the protein kinase Cdc7. We speculate that the dephosphorylation of Clb5-specific Cdk1 substrates and Dbf4-Cdc7 substrates drives the resolution of rDNA in early anaphase. The coincident destruction of securin, Clb5, and Dbf4 coordinates bulk chromosome segregation with segregation of rDNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.