ArticleJournal of invertebrate pathology2008
Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails.
Article in Journal of invertebrate pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- A systems-level analysis of global gene expression in resistant and susceptibleFrontiers in immunology · 2026Article
- Exploring the immune interactions between Oncomelania hupensis and Schistosoma japonicum, with a cross-comparison of immunological research progress in other intermediate host snails.Parasites & vectors · 2023Review
- Article
- Examining adaptive evolution of immune activity: opportunities provided by gastropods in the age of 'omics'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Sticky problems: extraction of nucleic acids from molluscs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Transcriptome profiling of Lymnaea stagnalis (Gastropoda) for ecoimmunological research.BMC genomics · 2021Article
- New Insights Into Biomphalysin Gene Family Diversification in the Vector SnailFrontiers in immunology · 2021Article
- An Overview of Transcriptional Responses of Schistosome-Susceptible (M line) or -Resistant (BS-90)Frontiers in immunology · 2021Article
- RNA-seq: The early response of the snail Physella acuta to the digenetic trematode Echinostoma paraensei.The Journal of parasitology · 2020Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
- Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate.Frontiers in immunology · 2017Article
- Differential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini.PLoS neglected tropical diseases · 2016Article
- Deep, multi-stage transcriptome of the schistosomiasis vector Biomphalaria glabrata provides platform for understanding molluscan disease-related pathways.BMC infectious diseases · 2016Article
- Digenean-gastropod host associations inform on aspects of specific immunity in snails.Developmental and comparative immunology · 2015Review
- A novel bacterial pathogen of Biomphalaria glabrata: a potential weapon for schistosomiasis control?PLoS neglected tropical diseases · 2015Article
- Article
- Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The snail Biomphalaria glabrata (Gastropoda, Mollusca) is an important intermediate host for the human parasite Schistosoma mansoni (Digenea, Trematoda). Anti-pathogen responses of B. glabrata were studied towards a better understanding of snail immunity and host-parasite compatibility. Open reading frame ESTs (ORESTES) were sampled from different transcriptomes of M line strain B. glabrata, 12h post-challenge with Escherichia coli (Gram-negative), Micrococcus luteus (Gram-positive) bacteria or compatible S. mansoni, and controls. The resulting 3123 ORESTES represented 2129 unique sequences (373 clusters, 1756 singletons). Of these, 175 (8.1%) were putative defense factors, including lectins, antimicrobial peptides and components of various immune-effector systems. Comparison of biological processes (GO-terms) within different transcriptomes indicated that B. glabrata increased oxygen transport and metal binding in reaction to all challenges. Comprehensive comparisons of transcriptomes revealed that responses of B. glabrata against bacteria were similar to each other and differed from the ineffective response to S. mansoni. Furthermore, the response to S. mansoni infection was less comprehensive than that to bacteria. Many novel (unknown) sequences were recovered in association with particular challenges. B. glabrata possesses multi-faceted, potent immune defenses. This agrees with the notion that S. mansoni is capable of immune-evasion and prevents effective host defense responses in order to survive in B. glabrata. Future analysis of the numerous unknown sequences recovered from challenged snails may reveal novel immune factors and provide increased understanding of immunity of B. glabrata in relation to parasite-host compatibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.