ArticleBMC microbiology2008
Molecular analysis of the emergence of pandemic Vibrio parahaemolyticus.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 140 citations in OpenAlex.
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- Insights on the regulation and function of the CRISPR/Cas transposition system located in the pathogenicity island VpaI-7 fromInfection and immunity · 2025Article
- Bile acids activate the antibacterial T6SS1 in the gut pathogenMicrobiology spectrum · 2024Article
- Public health aspects ofEFSA journal. European Food Safety Authority · 2024Article
- Meta-Analysis and Systematic Review of Phenotypic and Genotypic Antimicrobial Resistance and Virulence Factors inAntibiotics (Basel, Switzerland) · 2024Review
- Assessment of Vibrionaceae prevalence in seafood from Qidong market and analysis of Vibrio parahaemolyticus strains.PloS one · 2024Article
- A robust CRISPR interference gene repression system in Vibrio parahaemolyticus.Archives of microbiology · 2023Article
- Insights into virulence: structure classification of themSystems · 2023Article
- Antibiofilm Efficacy of Quercetin againstMicroorganisms · 2022Article
- Antimicrobial Efficacy of Quercetin againstPolymers · 2022Article
- Comparative Genomics of Clinical and Environmental Isolates ofPathogens (Basel, Switzerland) · 2021Article
- Whole genome analysis unveils genetic diversity and potential virulence determinants inVirulence · 2021Article
- Genomic stability among O3:K6 V. parahaemolyticus pandemic strains isolated between 1996 to 2012 in American countries.BMC genomic data · 2021Article
- Analysis of Secreted Proteins and Potential VirulenceFrontiers in microbiology · 2021Article
- Type III Secretion Effector VopQ of Vibrio parahaemolyticus Modulates Central Carbon Metabolism in Epithelial Cells.mSphere · 2020Article
- Comparative genomic analysis unravels the transmission pattern and intra-species divergence of acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio parahaemolyticus strains.Molecular genetics and genomics : MGG · 2019Article
- Carbohydrate metabolic systems present on genomic islands are lost and gained in Vibrio parahaemolyticus.BMC microbiology · 2019Article
- CRISPR-Cas systems are present predominantly on mobile genetic elements in Vibrio species.BMC genomics · 2019Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVibrio parahaemolyticus is abundant in the aquatic environment particularly in warmer waters and is the leading cause of seafood borne gastroenteritis worldwide. Prior to 1995, numerous V. parahaemolyticus serogroups were associated with disease, however, in that year an O3:K6 serogroup emerged in Southeast Asia causing large outbreaks and rapid hospitalizations. This new highly virulent strain is now globally disseminated.
resultsWe performed a four-way BLAST analysis on the genome sequence of V. parahaemolyticus RIMD2210633, an O3:K6 isolate from Japan recovered in 1996, versus the genomes of four published Vibrio species and constructed genome BLAST atlases. We identified 24 regions, gaps in the genome atlas, of greater than 10 kb that were unique to RIMD2210633. These 24 regions included an integron, f237 phage, 2 type III secretion systems (T3SS), a type VI secretion system (T6SS) and 7 Vibrio parahaemolyticus genomic islands (VPaI-1 to VPaI-7). Comparative genomic analysis of our fifth genome, V. parahaemolyticus AQ3810, an O3:K6 isolate recovered in 1983, identified four regions unique to each V. parahaemolyticus strain. Interestingly, AQ3810 did not encode 8 of the 24 regions unique to RMID, including a T6SS, which suggests an additional virulence mechanism in RIMD2210633. The distribution of only the VPaI regions was highly variable among a collection of 42 isolates and phylogenetic analysis of these isolates show that these regions are confined to a pathogenic clade.
conclusionOur data show that there is considerable genomic flux in this species and that the new highly virulent clone arose from an O3:K6 isolate that acquired at least seven novel regions, which included both a T3SS and a T6SS.
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