ArticleNeuropsychology2008
Neuroanatomical and cognitive mediators of age-related differences in episodic memory.
Article in Neuropsychology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Episodic memory impairment and its influencing factors in individuals with autism spectrum disorder: systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Effects of Healthy and Neuropathological Aging on Autobiographical Memory: A Meta-Analysis of Studies Using the Autobiographical Interview.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Pooled it
- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults.Hippocampus · 2020Trial
- Dopamine and memory dedifferentiation in aging.NeuroImage · 2017Trial
- Self-regulatory processes and exercise adherence in older adults: executive function and self-efficacy effects.American journal of preventive medicine · 2011Trial
- Effects of Reflective Processes on Social-Emotional Trait Development in Adulthood: Insights From Two Multi-Method Studies.Journal of personality · 2026Article
- Understanding the return journey: Determinants of route retracing in younger and older adults.Psychology and aging · 2025Article
- Is There a Link Between Older Adults' Frequency of (Face-to-Face and Remote) Contact With Grandchildren and Cognitive Functioning Over 12 Years?The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- How age and culture impact the neural correlates of memory retrieval.Cognitive, affective & behavioral neuroscience · 2025Article
- Subclinical depressive symptoms and job stress differentially impact memory in working and retired older adults.Scientific reports · 2025Article
- Mind-wandering when studying valuable information: The roles of age, dispositional traits, and contextual factors.Journal of experimental psychology. General · 2025Article
- Stem-cell-derived extracellular vesicles in neurodegeneration and neuroaging: therapeutic potential and challenges.Extracellular vesicles and circulating nucleic acids · 2025Review
- Effects of Age on Cross-Cultural Differences in the Neural Correlates of Memory Retrieval.bioRxiv : the preprint server for biology · 2024Article
- Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.Frontiers in aging neuroscience · 2024Article
- Regional covariance of white matter hyperintensity volume patterns associated with hippocampal volume in healthy aging.Frontiers in aging neuroscience · 2024Article
- Longitudinal changes in gray matter correspond to changes in cognition across the lifespan: implications for theories of cognition.Neurobiology of aging · 2023Article
- Associative memory is more strongly predicted by age-related differences in the prefrontal cortex than medial temporal lobes.Neuroimage. Reports · 2023Article
- Precipitating Mechanisms of Falls in Preclinical Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- The knowledge domain of cognitive neuroscience of aging: A Scientometric and bibliometric analysis.Frontiers in aging neuroscience · 2023Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aging is associated with declines in episodic memory. In this study, the authors used a path analysis framework to explore the mediating role of differences in brain structure, executive functions, and processing speed in age-related differences in episodic memory. Measures of regional brain volume (prefrontal gray and white matter, caudate, hippocampus, visual cortex), executive functions (working memory, inhibitory control, task switching, temporal processing), processing speed, and episodic memory were obtained in a sample of young and older adults. As expected, age was linked to reduction in regional brain volumes and cognitive performance. Moreover, neural and cognitive factors completely mediated age differences in episodic memory. Whereas hippocampal shrinkage directly affected episodic memory, prefrontal volumetric reductions influenced episodic memory via limitations in working memory and inhibitory control. Age-related slowing predicted reduced efficiency in temporal processing, working memory, and inhibitory control. Lastly, poorer temporal processing directly affected episodic memory. No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.