Evidence map›Paper›PMID 18589871›Full record

ArticleComparative medicine2008

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X.

Malgorzata Kamocka, Morris Pollard, Mark Suckow, Wojciech P Mielicki, Elliot D Rosen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Malgorzata KamockaMedical University of Lodz, Lodz, Poland. mkamocka@iupui.edu
Morris Pollard
Mark Suckow
Wojciech P Mielicki
Elliot D Rosen
Medical University of Lodz · PLUniversity of Notre Dame · USIndiana University · US

Funding

Rescue of Hemostasis-deficiency StatesP01HL073750 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J · 2004 to 2008
$8.8M
HEMOSTATIC BALANCE AND ARTERIAL THROMBOSISR01HL065241 · NHLBI · UNIVERSITY OF NOTRE DAME · PI ROSEN, ELLIOT DAVID · 2000 to 2004
$2.5M
NHLBI NIH HHS HL073750-01A1NHLBI NIH HHS P01 HL073750NHLBI NIH HHS R01 HL065241NHLBI NIH HHS R01HL65241-6
6 · The paper itself

Abstract

Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

Indexed as

AnimalsCysteine EndopeptidasesEnzyme-Linked Immunosorbent AssayFactor XMaleNeoplasm ProteinsProstatic NeoplasmsRatsRats, Wistarcancer procoagulantCysteine EndopeptidasesFactor XNeoplasm Proteins

Identifiers

PMID18589871
PMCPMC2704121
OpenAlexW130933168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.