ReviewComparative medicine2008
Fatigue and sleep during cancer and chemotherapy: translational rodent models.
Review in Comparative medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The impact of breast cancer treatment on sleep disturbance: a systematic review.Breast cancer research and treatment · 2025Pooled it
- Review
- Integrating Sleep Health Education in Cancer Care: Prevalence and Correlates of Insomnia Among Omani Patients Undergoing Chemotherapy.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Article
- Article
- Impact of fatigue on quality of life among breast cancer patients receiving chemotherapy.Osong public health and research perspectives · 2021Article
- Sleep health, diseases, and pain syndromes: findings from an electronic health record biobank.Sleep · 2021Article
- Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.Behavioural brain research · 2019Article
- Analysis of differences in exercise recognition by constraints on physical activity of hospitalized cancer patients based on their medical history.Journal of exercise rehabilitation · 2018Article
- Management of side effects during and post-treatment in breast cancer survivors.The breast journal · 2018Review
- Effects of mindfulness-based psychological care on mood and sleep of leukemia patients in chemotherapy.International journal of nursing sciences · 2017Article
- A murine model of peripheral irradiation-induced fatigue.Behavioural brain research · 2016Article
- Obstructive sleep apnea and cancer: Epidemiologic links and theoretical biological constructs.Sleep medicine reviews · 2016Review
- The role of physical rehabilitation in stem cell transplantation patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Review
- A high level of fatigue among long-term survivors of non-Hodgkin's lymphoma: results from the longitudinal population-based PROFILES registry in the south of the Netherlands.Haematologica · 2013Article
- Neurobiological studies of fatigue.Progress in neurobiology · 2012Review
- Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse.Cytokine · 2012Article
- Development of a mouse model for assessing fatigue during chemotherapy.Comparative medicine · 2011Article
- Efficacy of Ethyl Acetate Fraction ofIntegrative cancer therapiesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequent occurrence of fatigue and disturbed sleep in cancer survivors and the negative effect of these symptoms on quality of life and clinical outcome underscore the need to identify mechanisms that cause cancer-related fatigue, with a view toward developing more effective treatments for this problem. Human studies of fatigue and disturbed sleep are limited by high interindividual genetic and environmental variability, difficulties with behavioral or reporting compliance, and the subjective nature of the problems. Although animal models also must overcome the barrier of assessing fatigue and sleep disturbance in the absence of obvious objective clinical markers, animal studies are easier to control and standardize than are studies of people. Moreover, animal models are crucial to the identification and understanding of underlying disease mechanisms. This review describes the need for, the feasibility of, and several possible approaches to measuring fatigue in animal models of cancer and to relating such measures to disturbed sleep, immune function, and other potential mechanisms. Developing and using animal models to better understand fatigue and disturbed sleep related to cancer and its treatment has an enormous potential to expand the knowledge base and foster hypotheses necessary for the future development and testing of interventions.
Indexed as
Identifiers
18589865PMC2704115W101425442What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.