ReviewComparative medicine2008
Animal models of cancer pain.
Review in Comparative medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- Review
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- OBSERVE: guidelines for the refinement of rodent cancer models.Nature protocols · 2024Review
- Disease Animal Models for Cancer Research.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Effects of Three Consecutive Days of Morphine or Methadone Administration on Analgesia and Open-Field Activity in Mice with Ehrlich Carcinoma.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain.Journal of inflammation research · 2021Article
- Carbon fibers for treatment of cancer metastasis in bone.RSC advances · 2020Article
- circStrn3 is involved in bone cancer pain regulation in a rat model.Acta biochimica et biophysica Sinica · 2020Article
- Article
- Influence of Pain and Analgesia on Cancer Research Studies.Comparative medicine · 2019Review
- The Study of Pain in Rats and Mice.Comparative medicine · 2019Review
- Pain: Persistent postsurgery and bone cancer-related pain.The Journal of international medical research · 2019Review
- Review
- Inoculation of Lewis lung carcinoma cells enhances formalin-induced pain behavior and spinal Fos expression in mice.Journal of veterinary science · 2017Article
- Metastatic human breast cancer to the spine produces mechanical hyperalgesia and gait deficits in rodents.The spine journal : official journal of the North American Spine Society · 2017Article
- Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway.Molecules (Basel, Switzerland) · 2017Article
- Optimization andFrontiers in pharmacology · 2017Article
- Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.Disease models & mechanisms · 2016Article
- The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.Frontiers in pharmacology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 3 institutions in 1 country.
Funding
Abstract
Modern cancer therapies have significantly increased patient survival rates in both human and veterinary medicine. Since cancer patients live longer they now face new challenges resulting from severe, chronic tumor-induced pain. Unrelieved cancer pain significantly decreases the quality of life of such patients; thus the goal of pain management is to not only to alleviate pain, but also to maintain the patient's physiological and psychological well-being. The major impediment for developing new treatments for cancer pain has been our limited knowledge of the basic mechanisms that drive cancer pain and the lack of adequate animal cancer pain models to study the molecular, biochemical and neurobiological pathways that generate and maintain cancer pain. However this situation has recently changed with the recent development of several novel animal models of cancer pain. This review will focus on describing these animal models, many of them in rodents, and reviewing some of the recent information gained from the use of these models to investigate the basic mechanims that underlie the development and maintenance of cancer pain. Animal models of cancer pain can be divided into the following five categories: bone cancer pain models, non-bone cancer pain models, cancer invasion pain models, cancer chemotherapeutic-induced peripheral neuropathy models, and spontaneous occurring cancer pain models. These models will be important not only for enhancing our knowledge of how cancer pain is generated, but more importantly for the development of novel therapeutic regimes to treat cancer pain in both domestic animals and humans.
Indexed as
Identifiers
18589864PMC2704117W1479905500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.