ArticleAmerican journal of human genetics2008
A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Article
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- Linear Mixed-Effect Models Through the Lens of Hardy-Weinberg Disequilibrium.Frontiers in genetics · 2022Article
- Fitting Proportional Odds Model to Case-Control data with Incorporating Hardy-Weinberg Equilibrium.Scientific reports · 2015Article
- Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in patients with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Glioma Association and Balancing Selection of ZFPM2.PloS one · 2015Article
- Association of a polymorphism in a gene encoding a urate transporter with CKD progression.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Association of poly(ADP-ribose) polymerase-1 polymorphism with Tourette syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Association of tyrosyl-DNA phosphodiesterase 1 polymorphism with Tourette syndrome in Taiwanese patients.Journal of clinical laboratory analysis · 2013Article
- β-Arrestin2 influences the response to methadone in opioid-dependent patients.The pharmacogenomics journal · 2011Article
- Powerful multi-marker association tests: unifying genomic distance-based regression and logistic regression.Genetic epidemiology · 2010Article
- Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.Human molecular genetics · 2010Article
- Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin.Obesity (Silver Spring, Md.) · 2010Article
- Using both cases and controls for testing hardy-weinberg proportions in a genetic association study.Human heredity · 2010Article
- Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results.Human genetics · 2009Article
- Is the tail-strength measure more powerful in tests of genetic association?American journal of human genetics · 2009Article
- Tail strength to combine two p values: their correlation cannot be ignored.American journal of human genetics · 2009Article
- Apolipoprotein C3 polymorphisms, cognitive function and diabetes in Caribbean origin Hispanics.PloS one · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For assessment of genetic association between single-nucleotide polymorphisms (SNPs) and disease status, the logistic-regression model or generalized linear model is typically employed. However, testing for deviation from Hardy-Weinberg proportion in a patient group could be another approach for genetic-association studies. The Hardy-Weinberg proportion is one of the most important principles in population genetics. Deviation from Hardy-Weinberg proportion among cases (patients) could provide additional evidence for the association between SNPs and diseases. To develop a more powerful statistical test for genetic-association studies, we combined evidence about deviation from Hardy-Weinberg proportion in case subjects and standard regression approaches that use case and control subjects. In this paper, we propose two approaches for combining such information: the mean-based tail-strength measure and the median-based tail-strength measure. These measures integrate logistic regression and Hardy-Weinberg-proportion tests for the study of the association between a binary disease outcome and an SNP on the basis of case- and control-subject data. For both mean-based and median-based tail-strength measures, we derived exact formulas to compute p values. We also developed an approach for obtaining empirical p values with the use of a resampling procedure. Results from simulation studies and real-disease studies demonstrate that the proposed approach is more powerful than the traditional logistic-regression model. The type I error probabilities of our approach were also well controlled.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.