ReviewTransplantation proceedings2008
Composite tissue transplantation: a rapidly advancing field.
Review in Transplantation proceedings, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Evaluation of the effects of ischemia-reperfusion injury in rat isogenic and allogeneic muscle and skin transplant models.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Hand Transplantation-Risks and Benefits.Journal of hand and microsurgery · 2021Review
- The history of microsurgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Review
- Technology and vascularized composite allotransplantation (VCA)-lessons learned from the first bilateral pediatric hand transplant.Journal of materials science. Materials in medicine · 2016Review
- Key psychosocial challenges in vascularized composite allotransplantation.World journal of transplantation · 2016Review
- Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance.Transplantation · 2013Article
- Expression and purification of enterovirus type 71 polyprotein P1 using Pichia pastoris system.Virologica Sinica · 2012Article
- The need for inducing tolerance in vascularized composite allotransplantation.Clinical & developmental immunology · 2012Review
- Role of donor-specific regulatory T cells in long-term acceptance of rat hind limb allograft.PloS one · 2012Article
- Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants.Transplantation · 2011Article
- Future perspectives for hand transplant in iran.International journal of organ transplantation medicine · 2011Article
- Article
- An economic analysis of hand transplantation in the United States.Plastic and reconstructive surgery · 2010Article
- Hand allotransplantation.Seminars in plastic surgery · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Composite tissue allotransplantation (CTA) is emerging as a potential treatment for complex tissue defects. It is currently being performed with increasing frequency in the clinic. The feasibility of the procedure has been confirmed through 30 hand transplantation, 3 facial reconstructions, and vascularized knee, esophageal, and tracheal allografts. A major drawback for CTA is the requirement for lifelong immunosuppression. The toxicity of these agents has limited the widespread application of CTA. Methods to reduce or eliminate the requirement for immunosuppression and promote CTA acceptance would represent a significant step forward in the field. Multiple studies suggest that mixed chimerism established by bone marrow transplantation promotes tolerance resulting in allograft acceptance. This overview focuses on the history and the exponentially expanding applications of the new frontier in CTA transplantation: immunology associated with CTA; preclinical animal models of CTA; clinical experience with CTA; and advances in mixed chimerism-induced tolerance in CTA. Additionally, some important hurdles that must be overcome in using bone marrow chimerism to induce tolerance to CTA are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.