ArticleNeurobiology of disease2008
Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures.
Article in Neurobiology of disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- HIV and Cocaine exposure promote Tau phosphorylation through RSK-1 in a GSK3β-independent manner.bioRxiv : the preprint server for biology · 2026Article
- An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction.Neuroscience and biobehavioral reviews · 2021Review
- Review
- Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.Molecular neurobiology · 2019Article
- Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration.International journal of molecular sciences · 2019Review
- High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin.Molecular neurobiology · 2018Article
- MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.Molecular neurobiology · 2016Article
- In vitro aggregation assays using hyperphosphorylated tau protein.Journal of visualized experiments : JoVE · 2015Article
- Protein phosphorylation in neurodegeneration: friend or foe?Frontiers in molecular neuroscience · 2014Review
- Are tau aggregates toxic or protective in tauopathies?Frontiers in neurology · 2013Article
- Hsp70 alters tau function and aggregation in an isoform specific manner.Biochemistry · 2012Article
- Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.International journal of Alzheimer's disease · 2012Article
- Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.Biochemistry · 2011Article
- Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization.Biochemistry · 2009Article
- GSK-3beta phosphorylation of functionally distinct tau isoforms has differential, but mild effects.Molecular neurodegeneration · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hyperphosphorylated tau protein is a major component of neurofibrillary tangles, a prominent intracellular hallmark of Alzheimer's disease. Both hyperphosphorylated tau and neurofibrillary tangles have been shown to correlate with dementia in Alzheimer's disease, but the relationship between hyperphosphorylation and tangle formation is not clear. Using a cell-free in vitro model system, in which tau polymerization is induced by arachidonic acid, we show that GSK-3beta phosphorylation of pre-assembled tau filaments makes those filaments prone to coalesce into large neurofibrillary tangle-like structures. Five phosphorylation sites, S199, T205, T231, S396 and S404, were identified in the phosphorylated filaments; many of the five are within epitopes recognized by Alzheimer's disease-associated antibodies. These tangle-like structures are optically visible and are similar to those formed by polymerization of GSK-3beta phosphorylated tau monomer and to those isolated from Alzheimer's disease tissue. We conclude that the phosphorylation of tau by GSK-3beta either prior to or following polymerization promotes polymer/polymer interactions that result in stable clusters of tau filaments.
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Registered trials
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