ArticleBMC cancer2008
Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro.
Article in BMC cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Characterization of tumors of jaw: Additive value of contrast enhancement and dual-energy computed tomography.World journal of radiology · 2024Article
- Molecular biological findings of ameloblastoma.The Japanese dental science review · 2021Review
- Upregulation of interleukin-8 and activin A induces osteoclastogenesis in ameloblastoma.International journal of molecular medicine · 2019Article
- Immunohistochemistry of Five Molecular Markers for Typing and Management of Ameloblastomas: A Retrospective Analysis of 40 Cases.Journal of maxillofacial and oral surgery · 2017Article
- PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2016Article
- EGFR signaling downstream of EGF regulates migration, invasion, and MMP secretion of immortalized cells derived from human ameloblastoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix metalloproteinase-2.ACS nano · 2013Article
- Epigenetic regulation of matrix metalloproteinase expression in ameloblastoma.BMC clinical pathology · 2012Article
- Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.Free radical biology & medicine · 2012Article
- Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma.International journal of clinical and experimental pathology · 2012Article
- Molecular markers of tumor invasiveness in ameloblastoma: An update.Annals of maxillofacial surgery · 2011Article
- Granular cell ameloblastoma: an unusual histological subtype report and review of literature.Journal of oral & maxillofacial research · 2011Article
- Expression of RECK and matrix metalloproteinase-2 in ameloblastoma.BMC cancer · 2009Article
- Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration.Histochemistry and cell biology · 2009Article
- Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion.World journal of gastroenterology · 2009Article
- Association of matrix metalloproteinase 2 and matrix metalloproteinase 9 gene polymorphism in aggressive and nonaggressive odontogenic lesions: A pilot study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor.European journal of dentistryArticle
- Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas.Journal of oral biology and craniofacial researchArticle
- Quantitative evaluation of microvessel density using CD34 in clinical variants of ameloblastoma: An immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Alpha-tocopherol Levels in Predicting the Biological Behaviour of Ameloblastoma - A Comparative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmeloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas.
methodsPlasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were created and subsequently transfected into primary ameloblastoma cells. Zymography, RT-PCR, and Western blots were used to assess MMP-2 activity and expression of MMP-2 and TIMP-2, as well as protein levels.
resultsPrimary cultures of ameloblastoma cells expressed cytokeratin (CK) 14 and 16, and MMP-2, but only weakly expressed CK18 and vimentin. MMP-2 mRNA and protein levels were significantly inhibited by RNA interference (P < 0.05). Both MMP-2 siRNA and TIMP-2 overexpression inhibited MMP-2 activity and the in vitro invasiveness of ameloblastoma.
conclusionThese results indicate that inhibition of MMP-2 activity suppresses the local invasiveness of ameloblastoma cells. This mechanism may serve as a novel therapeutic target in ameloblastomas pursuant to additional research.
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