ArticleBMC medical genetics2008
Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Article
- GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.Current medical science · 2018Article
- Fine-mapping markers of lung cancer susceptibility in a sub-region of chromosome 19q13.3 among Chinese.Oncotarget · 2016Article
- Increased expression of iASPP correlates with poor prognosis in FIGO IA2-IIA cervical adenocarcinoma following a curative resection.American journal of cancer research · 2015Article
- ProSim: A Method for Prioritizing Disease Genes Based on Protein Proximity and Disease Similarity.BioMed research international · 2015Article
- Article
- In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP.International journal of clinical and experimental pathology · 2014Article
- Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines.Cancer cell international · 2013Article
- PPP1R13L variant associated with prognosis for patients with rectal cancer.Journal of cancer research and clinical oncology · 2013Article
- copy number variation analysis in familial BRCA1/2-negative Finnish breast and ovarian cancer.PloS one · 2013Article
- Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.BMC medical genetics · 2009Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious results have suggested an association of the region of 19q13.3 with several forms of cancer. In the present study, we investigated 27 public markers within a previously identified 69 kb stretch of chromosome 19q for association with breast cancer by using linkage disequilibrium mapping. The study groups included 434 postmenopausal breast cancer cases and an identical number of individually matched controls. METHODS AND
resultsStudying one marker at a time, we found a region spanning the gene RAI (alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer. The region corresponds to a haplotype block, in which there seems to be very limited recombination in the Danish population. Studying combinations of markers, we found that two to four neighboring markers gave the most consistent and strongest result. The haplotypes with strongest association with cancers were located in the gene RAI and just 3' to the gene. Coinciding peaks were seen in the region of RAI in groups of women of different age. In a follow-up to these results we sequenced 10 cases and 10 controls in a 44 kb region spanning the peaks of association. This revealed 106 polymorphisms, many of which were not in the public databases. We tested an additional 44 of these for association with disease and found a new tandem repeat marker, called RAI-3'd1, located downstream of the transcribed region of RAI, which was more strongly associated with breast cancer than any other marker we have tested (RR = 2.44 (1.41-4.23, p = 0.0008, all cases; RR = 6.29 (1.49-26.6), p = 0.01, cases up to 55 years of age).
conclusionWe expect the marker RAI-3'd1 to be (part of) the cause for the association of the chromosome 19q13.3 region's association with cancer.
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