ArticleThe European journal of neuroscience2008
Temporally limited role of substantia nigra-central amygdala connections in surprise-induced enhancement of learning.
Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Surprise-induced enhancements in the associability of Pavlovian cues facilitate learning across behavior systems.Behavioral neuroscience · 2022Article
- Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse.Neuroscience bulletin · 2020Article
- An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI.Frontiers in neuroscience · 2019Article
- Abundant collateralization of temporal lobe projections to the accumbens, bed nucleus of stria terminalis, central amygdala and lateral septum.Brain structure & function · 2017Article
- Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice.eLife · 2017Article
- Consolidation of altered associability information by amygdala central nucleus.Neurobiology of learning and memory · 2016Article
- Secondary visual cortex is critical to the expression of surprise-induced enhancements in cue associability in rats.The European journal of neuroscience · 2016Article
- Mini-review: Prediction errors, attention and associative learning.Neurobiology of learning and memory · 2016Review
- Dorsolateral striatum is critical for the expression of surprise-induced enhancements in cue associability.The European journal of neuroscience · 2015Article
- Amygdalo-striatal interaction in the enhancement of stimulus salience in associative learning.Behavioral neuroscience · 2015Article
- Role of lateral hypothalamus in two aspects of attention in associative learning.The European journal of neuroscience · 2014Article
- Posterior parietal cortex is critical for the encoding, consolidation, and retrieval of a memory that guides attention for learning.The European journal of neuroscience · 2014Article
- Contribution of emotional and motivational neurocircuitry to cue-signaled active avoidance learning.Frontiers in behavioral neuroscience · 2014Review
- Homeostatic regulation of memory systems and adaptive decisions.Hippocampus · 2013Review
- Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus.Frontiers in behavioral neuroscience · 2013Article
- Attention-related Pearce-Kaye-Hall signals in basolateral amygdala require the midbrain dopaminergic system.Biological psychiatry · 2012Article
- Role of amygdala central nucleus in feature negative discriminations.Behavioral neuroscience · 2012Article
- The effects of basolateral amygdala lesions on unblocking.Behavioral neuroscience · 2012Article
- Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors.The Journal of comparative neurology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prediction error plays an important role in modern associative learning theories. For example, the omission of an expected event (surprise) can enhance attention to cues that accompany those omissions, such that subsequent new learning about those cues is more rapid. Many studies from our laboratories have demonstrated that circuitry that includes the amygdala central nucleus (CeA), the cholinergic neurons in the substantia innominata/nucleus basalis region and their innervation of the posterior parietal cortex is critical for this surprise-induced enhancement of attention in learning. We recently showed that midbrain dopamine neurons, known to code prediction error, are also important for surprise-induced enhancement of learning through their interaction with CeA. The present study examined whether in rats the communication between the substantia nigra pars compacta (SNc) and CeA is critical only at the time of surprise, for example to detect prediction error information, or is also needed to maintain and later express that information as enhanced learning. All animals received unilateral CeA lesions and unilateral cannula implants targeting the SNc located contralateral to the lesioned CeA. As the SNc-CeA connections are mainly ipsilateral, inactivating SNc contralateral to the lesioned CeA provided transient blockage of SNc and CeA communication. The results show that SNc-CeA communication is critical for processing prediction error information at the time of surprise, but neither SNc nor SNc-CeA communication is necessary to express that information as enhanced learning later.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.