ArticleThe European journal of neuroscience2008
Neurogenesis, learning and associative strength.
Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Pathogenesis, Assessments, and Management of Chemotherapy-Related Cognitive Impairment (CRCI): An Updated Literature Review.Journal of oncology · 2020Review
- Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory.Brain research · 2016Review
- MAP training: combining meditation and aerobic exercise reduces depression and rumination while enhancing synchronized brain activity.Translational psychiatry · 2016Article
- Sexual Conspecific Aggressive Response (SCAR): A Model of Sexual Trauma that Disrupts Maternal Learning and Plasticity in the Female Brain.Scientific reports · 2016Article
- Negative neuroplasticity in chronic traumatic brain injury and implications for neurorehabilitation.Neuropsychology review · 2014Review
- Mental and Physical (MAP) Training: a neurogenesis-inspired intervention that enhances health in humans.Neurobiology of learning and memory · 2014Review
- Preparing for adulthood: thousands upon thousands of new cells are born in the hippocampus during puberty, and most survive with effortful learning.Frontiers in neuroscience · 2014Article
- Stress and addiction.Psychoneuroendocrinology · 2013Review
- Hippocampus-dependent learning influences hippocampal neurogenesis.Frontiers in neuroscience · 2013Article
- Training your brain: Do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus?Neuropharmacology · 2013Review
- Physical skill training increases the number of surviving new cells in the adult hippocampus.PloS one · 2013Article
- Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain.The European journal of neuroscience · 2012Article
- Moderate drinking? Alcohol consumption significantly decreases neurogenesis in the adult hippocampus.Neuroscience · 2012Article
- Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.Neurobiology of aging · 2012Article
- Use it or lose it: how neurogenesis keeps the brain fit for learning.Behavioural brain research · 2012Review
- Learning to learn: theta oscillations predict new learning, which enhances related learning and neurogenesis.PloS one · 2012Article
- From chemical neuroanatomy to an understanding of the olfactory system.European journal of histochemistry : EJH · 2011Review
- Learning increases the survival of newborn neurons provided that learning is difficult to achieve and successful.Journal of cognitive neuroscience · 2011Article
- Changing the rate and hippocampal dependence of trace eyeblink conditioning: slow learning enhances survival of new neurons.Neurobiology of learning and memory · 2011Article
- Associative learning increases adult neurogenesis during a critical period.The European journal of neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Though the role of the hippocampus in processes of learning and memory is well established, the role of new neurons generated there is less understood. Training on some associative learning tasks increases the likelihood that new cells in the subgranular zone of the dentate gyrus will survive. In the rat, an effective training procedure is trace eyeblink conditioning, in which a conditioned stimulus (CS) is paired with an aversive stimulation to the eyelid (unconditioned stimulus; US), but the stimuli are separated by a temporal gap. Here, we manipulated the asymptote or rate of acquisition during trace conditioning, and examined survival of cells generated 1 week before training. Acquisition was disrupted by decreasing associative strength by insertion of unpredicted USs or slowed with latent inhibition. The number of cells was increased in animals that were trained with trace conditioning, irrespective of the decrease in associative strength or slowed acquisition. Disrupting acquisition with unsignaled USs still increased cell numbers, suggesting that the learning effect on cell survival is not dependent on reliable expression of the conditioned response. Further, animals in the latent inhibition conditions that learned but required more trials also retained more of the new cells than animals requiring fewer trials. The number of cells that survived after the effective training procedures was similar to the number of cells that were available for rescue at the beginning of training. Thus, learning can rescue the majority of cells expressed at the beginning of training, and does so most effectively when acquisition requires many trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.